Formate dehydrogenase: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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-{{STRUCTURE_2nad|  PDB=2nad  | SIZE=400| SCENE= |right|CAPTION=NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate,  [[2nad]]}}
+<StructureSection load='' size='350' side='right' scene='49/491980/Cv/1' caption='NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate,  [[2nad]]'>
-<!--
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate.  The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome.  The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.
-Or use the four-green-boxes-button to insert scrollable text adjacent
+*<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
-to a Jmol applet. Check out the other buttons as well!
+*<scene name='49/491980/Cv/9'>Azide ion binding site</scene>.
--->
-'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate.  The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe4S4 center and then to cytochrome.  The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe4S4.
 ==3D structure of formate dehydrogenase==
+[[Formate dehydrogenase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-'''NAD-dependent FDH'''
-[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
-[[2fss]] – CbFDH – ''Candida boidinii''<BR />
-[[2j6i]] – CbFDH C terminal (mutant) <BR />
-[[3fn4]] - MoFDH – ''Moraxella''<BR />
-[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
-[[2nad]] – PsFDH + NAD<BR />
-[[2gug]] – PsFDH + formate<BR />
-[[2gsd]] – MoFDH + NAD + N3<BR />
-[[3n7u]] - ArFDH + NAD + N3<BR />
-'''Mo-dependent FDH'''
-[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR />
+== References ==
-[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
+<references/>
-[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
-[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
-[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
 [[Category:Topic Page]]