Flavodoxin: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(19 intermediate revisions by 3 users not shown)
Line 1: Line 1:
[[Image:2bmv.png|left|200px|thumb|Crystal Structure of Flavodoxin, [[2bmv]]]]
<StructureSection load='2bmv' size='350' side='right' scene='41/413119/Cv/2' caption='Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion (PDB code [[2bmv]]) '>
{{STRUCTURE_2bmv|  PDB=2bmv  | SIZE=300| SCENE=Flavodoxin/Cv/1 |right|CAPTION=Apo-Flavodoxin from ''Helicobacter pylori'', [[2bmv]] }}


[[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD).  It participates in nitrogen metabolism and reduces N2 to NH3 while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red.  NrdI is a FDX which is involved in ribonucleotide reduction.  WrbA (tryptophan Repressor-Binding Protein) is also FDX.  In ''E. coli'' there are 2 distinct FDX I and II. The images at the left and at the right correspond to one representative FDX structure, ''i.e.'' the crystal structure of apo-flavodoxin from ''Helicobacter pylori'' ([[2bmv]]).  The space filling objects are of chloride ion and benzamidine.
[[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD).  It participates in nitrogen metabolism and reduces N<sub>2</sub> to NH<sub>3</sub> while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red<ref>PMID:9416602</ref>.  '''NrdI''' is a FDX which is involved in ribonucleotide reduction.  '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX.  In ''E. coli'' there are 2 distinct flavodoxins: FDX I and II.


{{TOC limit|limit=2}}
*<scene name='41/413119/Cv/5'>Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion</scene>.
*<scene name='41/413119/Cv/6'>Cl coordination site</scene>. Water molecules shown as red spheres.


== 3D Structures of Flavodoxin ==
== 3D Structures of Flavodoxin ==
[[Flavodoxin 3D structures]]


</StructureSection>


=== Apo FDX ===
== References ==
<references/>


[[2kqu]], [[1dx9]] – AnFDX (mutant) apo – ''Anabanea'' – NMR<br />
[[Category:Topic Page]]
[[2bmv]] – HpFDX apo - ''Helicobacter pylori''<br />
[[3d7n]] – FDX apo – ''Agrobacterium tumefaciens''<br />
[[2rg1]] - EcFDX WrbA apo - ''Escherichia coli''<br />
[[2hna]], [[2hnb]] – EcFDX apo – NMR<br />
[[1qhe]], [[1ftg]] – nFDX apo – Nostoc<br />
[[1bu5]] – DvFDX apo+riboflavin - ''Desulfovibrio vulgaris''<br />
 
 
 
=== FDX containing FMN oxidized (quinone) ===
 
 
[[3f6r]], [[3f6s]], [[3kap]] – DdFDX-ox - ''Desulfovibrio desulfuricans''<br />
[[1ag9]] – EcFDX-ox<br />
[[1flv]] – nFDX-ox<br />
[[1xyy]], [[1j9g]], [[1c7f]], [[1akr]], [[1akt]], [[1akw]] – DvFDX-ox (mutant)<br />
[[2fx2]], [[3fx2]], [[4fx2]], [[5fx2]], [[1fx1]] – DvFDX-ox<br />
[[1czk]], [[1czr]] – SeFDX-ox (mutant) - ''Synechococcus elongates''<br />
[[1czn]] – SeFDX-ox I<br />
[[1ofv]] – SeFDX-ox II<br />
[[1czu]], [[1d03]] - SeFDX-ox II<br />
[[2fdx]], [[1fld]], [[1fvx]], [[2fax]], [[3nll]], [[4nll]], [[4nul]], [[5nll]] – CbFDX-ox (mutant) - ''Clostridium beijerinckii''<br />
[[2fcr]] – FDX-ox – ''Chondrus crispus''<br />
[[1fue]] – HpFDX-ox
 
=== FDX containing FMNH (semiquinone) ===
 
 
[[2x2o]], [[2x2p]] – NrdI-sq – ''Bacillus cereus''<br />
[[3kaq]], [[3f90]] – DdFDX-sq <br />
[[1xt6]], [[1wsw]], [[1xyv]], [[1akv]], [[1wsb]] - DvFDX-sq (mutant)<br />
[[1czh]], [[1czl]] - SeFDX-sq (mutant)<br />
[[2fox]], [[5nul]]– CbFDX-sq<br />
 
 
=== FDX containing FMNH2 (hydroquinone) ===
 
[[2fz5]] – FDX-red – ''Megasphaera elsdenii'' – NMR<br />
[[1c7e]], [[1aku]], [[1akq]] - DvFDX-red (mutant)<br />
[[1czo]] - SeFDX-red (mutant)<br />
[[1d04]] – SeFDX-red<br />
[[1fla]], [[1fln]], [[2flv]], [[2fvx]], [[5ull]], [[6nul]] – CbFDX-red (mutant)<br />
 
 
=== Other FDX ===
 
 
[[3esx]], [[3esy]], [[3esz]], [[2v5u]], [[2v5v]], [[1obo]], [[1obv]] - AnFDX (mutant)<br />
[[1rcf]], [[1flv]] - AnFDX<br />
[[2wc1]] – FDX – ''Rhodobacter capsulatus''<br />
[[2w5u]] – HpFDX+C3 inhibitor 1fue - HpFDX<br />
[[2kaq]] – DdFDX <br />
[[2r97]], [[2r96]] – EcFDX WrbA<br />
[[1ahn]] – EcFDX<br />
[[2q9u]] – FDX di-iron – ''Giardia intestinalis''<br />
[[2ark]] – FDX – ''Aquifex aeolicus''<br />
[[1yob]] – FDX II – ''Azotobacter vinelandii''<br />
[[1j9e]], [[1f4p]], [[1i10]], [[1azl]] – DvFDX (mutant)<br />
[[1j8q]] - DvFDX<br />

Latest revision as of 11:11, 3 July 2019


Flavodoxin (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N2 to NH3 while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red[1]. NrdI is a FDX which is involved in ribonucleotide reduction. WrbA (Tryptophan Repressor-Binding Protein) is also FDX. In E. coli there are 2 distinct flavodoxins: FDX I and II.

  • .
  • . Water molecules shown as red spheres.

3D Structures of Flavodoxin

Flavodoxin 3D structures


Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion (PDB code 2bmv)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Hoover DM, Ludwig ML. A flavodoxin that is required for enzyme activation: the structure of oxidized flavodoxin from Escherichia coli at 1.8 A resolution. Protein Sci. 1997 Dec;6(12):2525-37. PMID:9416602 doi:10.1002/pro.5560061205

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Flavodoxin&oldid=3064164"