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| [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin FnI<sub>4-5</sub> fragment [[1fbr]]]]
| | <StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '> |
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| <StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '> | |
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| == Function == | | == Function == |
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| == Disease == | | == Disease == |
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| Overexpression of Fn1 is associated with lung cancer. | | Overexpression of Fn1 is associated with lung cancer<ref>PMID:16397245</ref>. |
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| == Structural insights == | | == Structural insights == |
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| Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD). | | <scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD). |
| </StructureSection>
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| == 3D Structures of Fibronectin == | | == 3D Structures of Fibronectin == |
| | [[Fibronectin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Fn module FnI
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| **[[3m7p]] – hFn GBD – human<br />
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| **[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
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| **[[3gxe]], [[3ejh]] – hFnI<sub>8-9</sub> +collagen alpha-1<br />
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| **[[1fbr]] - hFnI<sub>4-5</sub> - NMR<br />
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| **[[2rky]], [[2rl0]] – hFnI<sub>4-5</sub>+Fn binding peptide<br />
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| **[[2rkz]], [[3cal]], [[3zrz]] - hFn<sub>2-3</sub> +Fn binding peptide<br />
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| **[[2cg6]], [[2cg7]] - hFnI<sub>2-3</sub><br />
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| **[[2cku]] - hFnI<sub>2-3</sub> – NMR<br />
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| **[[1o9a]] - hFnI<sub>1-2</sub>+B3 from FNBB – NMR<br />
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| **[[2ec3]] – hFnI<sub>11</sub> – NMR<br />
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| **[[3r8q]] – hFnI<sub>12-14</sub><br />
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| **[[1qgb]] – hFn FnI N-terminal - NMR<br />
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| **[[2ck2]] – hFn (mutant) core swapped<br />
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| **[[1j8k]] – hFn extra domain 2 – NMR<br />
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| **[[1fnh]] – hFn heparin and integrin binding domains<br />
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| **[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
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| **[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
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| * Fn module FnII
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| **[[2fn2]] – hFnII<sub>2</sub> – NMR
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| * Fn module FnIII
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| **[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
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| **[[2h41]], [[2h45]] – hFnIII<sub>2</sub> – NMR<br />
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| **[[1oww]] - hFnIII<sub>1</sub> – NMR<br />
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| **[[2ha1]] - hFnIII<sub>1-2</sub> – NMR<br />
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| **[[2crm]] - hFnIII<sub>4</sub> – NMR<br />
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| **[[2crz]] - hFnIII<sub>5</sub> – NMR<br />
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| **[[1fna]], [[1ttf]], [[1ttg]] – hFnIII<sub>10</sub><br />
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| **[[4mmx]] - hFnIII<sub>10</sub> + integrin α V + integrin β 3<br />
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| **[[4mmy]], [[4mmz]] - hFnIII<sub>10</sub> (mutant) + integrin α V + integrin β 3<br />
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| **[[2ocf]] - hFnIII<sub>10</sub>+estrogen receptor ligand-binding domain<br />
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| **[[1fnf]] – hFnIII<sub>7-10</sub><br />
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| **[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
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| **[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />
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| **[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
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| * Fn module FnI+FnII
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| **[[3mql]] – hFnI<sub>6</sub>+FnII<sub>2</sub>+FnI<sub>7</sub>
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |