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| [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI<sub>4-5</sub> fragment [[1fbr]]]]
| | <StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '> |
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| <StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '> | |
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| == Function == | | == Function == |
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| == Disease == | | == Disease == |
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| Overexpression of Fn1 is associated with lung cancer. | | Overexpression of Fn1 is associated with lung cancer<ref>PMID:16397245</ref>. |
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| == Structural insights == | | == Structural insights == |
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| Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD). | | <scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD). |
| </StructureSection>
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| == 3D Structures of Fibronectin == | | == 3D Structures of Fibronectin == |
| | [[Fibronectin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Fn module FnI
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| **[[3m7p]] – hFn GBD – human<br />
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| **[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
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| **[[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br />
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| **[[1fbr]] - hFn 4-5FnI - NMR<br />
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| **[[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br />
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| **[[2rkz]], [[3cal]], [[3zrz]] - hFn 2-3FnI+Fn binding peptide<br />
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| **[[2cg6]], [[2cg7]] - hFn 2-3FnI<br />
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| **[[2cku]] - hFn 2-3FnI – NMR<br />
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| **[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br />
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| **[[2ec3]] – hFn 11FnI – NMR<br />
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| **[[3r8q]] – hFn 12-14FnI<br />
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| **[[1qgb]] – hFn FnI N-terminal - NMR<br />
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| **[[2ck2]] – hFn (mutant) core swapped<br />
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| **[[1j8k]] – hFn extra domain 2 – NMR<br />
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| **[[1fnh]] – hFn heparin and integrin binding domains<br />
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| **[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
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| **[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
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| * Fn module FnII
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| **[[2fn2]] – hFn 2FnII – NMR
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| * Fn module FnIII
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| **[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
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| **[[2h41]], [[2h45]] – hFn 2FnIII – NMR<br />
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| **[[1oww]] - hFn 1FnIII – NMR<br />
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| **[[2ha1]] - hFn 1-2FnIII – NMR<br />
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| **[[2crm]] - hFn 4FnIII – NMR<br />
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| **[[2crz]] - hFn 5FnIII – NMR<br />
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| **[[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br />
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| **[[4mmx]] - hFn 10FnIII + integrin α V + integrin β 3<br />
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| **[[4mmy]], [[4mmz]] - hFn 10FnIII (mutant) + integrin α V + integrin β 3<br />
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| **[[2ocf]] - hFn 10FnIII+estrogen receptor ligand-binding domain<br />
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| **[[1fnf]] – hFn 7-10FnIII<br />
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| **[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
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| **[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br />
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| **[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
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| * Fn module FnI+FnII
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| **[[3mql]] – hFn 6FnI+2FnII+7FnI
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |