Fibronectin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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-[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]]
+<StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>
-{{STRUCTURE_3m7p|  PDB=3m7p  | SIZE=400| SCENE= |right|CAPTION=Human fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions [[3m7p]] }}
+== Function ==
+[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others.  It is a component of cell adhesion<ref>PMID:12244123</ref>.
+== Relevance ==
+Fn is associated with wound healing. Fn is a potential marker for radiation resistance.
+== Disease ==
+Overexpression of Fn1 is associated with lung cancer<ref>PMID:16397245</ref>.
+== Structural insights ==
+<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).
-[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others.  It is a component of cell adhesion.  It is a dimer of homologous monomers linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment  ([[1fbr]]).
-{{TOC limit|limit=2}}
 == 3D Structures of Fibronectin ==
+[[Fibronectin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-=== Fn module FnI ===
-[[3m7p]] – hFn GBD – human<br />
-[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
-[[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br />
-[[1fbr]] - hFn 4-5FnI - NMR<br />
-[[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br />
-[[2rkz]], [[3cal]] - hFn 2-3FnI+Fn binding peptide<br />
-[[2cg6]], [[2cg7]] - hFn 2-3FnI<br />
-[[2cku]] - hFn 2-3FnI – NMR<br />
-[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br />
-[[2ec3]] – hFn 11FnI – NMR<br />
-[[3r8q]] – hFn 12-14FnI<br />
-[[1qgb]] – hFn FnI N-terminal - NMR<br />
-[[2ck2]] – hFn (mutant) core swapped<br />
-[[1j8k]] – hFn extra domain 2 – NMR<br />
-[[1fnh]] – hFn heparin and integrin binding domains<br />
-[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
-[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
-=== Fn module FnII ===
-[[2fn2]] – hFn 2FnII – NMR
-=== Fn module FnIII ===
-[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
-[[2h41]], [[2h45]] – hFn 2FnIII – NMR<br />
-[[1oww]] - hFn 1FnIII – NMR<br />
-[[2ha1]] - hFn 1-2FnIII – NMR<br />
-[[2crm]] - hFn 4FnIII – NMR<br />
-[[2crz]] - hFn 5FnIII – NMR<br />
-[[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br />
-[[2ocf]] - hFn 10FnIII+estrogen receptor ligand-binding domain<br />
-[[1fnf]] – hFn 7-10FnIII<br />
-[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
-[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br />
-[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
-=== Fn module FnI+FnII ===
-[[3mql]] – hFn 6FnI+2FnII+7FnI
+== References ==
+<references/>
 [[Category:Topic Page]]