6gnq: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6gnq is ON HOLD
+==Monoclinic crystalline form of human insulin, complexed with meta-cresol==
+<StructureSection load='6gnq' size='340' side='right'caption='[[6gnq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Margiolaki, I., Karavassili, F., Valmas, A., Dimarogona, M., Giannopoulou, A.E., Fili, S., Schluckebier, G., Norrman, M., Beckers, D., Fitch, A.N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gnq]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GNQ FirstGlance]. <br>
-Description: Monoclinic crystalline form of human insulin, complexed with meta-cresol
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IS8:isothiocyanate'>IS8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gnq OCA], [http://pdbe.org/6gnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gnq RCSB], [http://www.ebi.ac.uk/pdbsum/6gnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gnq ProSAT]</span></td></tr>
-[[Category: Valmas, A]]
+</table>
-[[Category: Giannopoulou, A.E]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[http://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref>   Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[http://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref>   Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[http://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref>   Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[http://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Beckers, D]]
 [[Category: Dimarogona, M]]
-[[Category: Schluckebier, G]]
+[[Category: Fili, S]]
+[[Category: Fitch, A N]]
+[[Category: Giannopoulou, A E]]
 [[Category: Karavassili, F]]
+[[Category: Margiolaki, I]]
 [[Category: Norrman, M]]
-[[Category: Beckers, D]]
+[[Category: Schluckebier, G]]
-[[Category: Fili, S]]
+[[Category: Valmas, A]]
-[[Category: Fitch, A.N]]
+[[Category: Complex]]
-[[Category: Margiolaki, I]]
+[[Category: Hexamer]]
+[[Category: Hormone]]
+[[Category: Human insulin]]
+[[Category: Meta-cresol]]