6f3c: Difference between revisions
New page: '''Unreleased structure''' The entry 6f3c is ON HOLD Authors: Ferraroni, M., Bazzicalupi, C., Gratteri, P., Papi, F. Description: The cytotoxic [Pt(H2bapbpy)] platinum complex interact... |
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The | ==The cytotoxic [Pt(H2bapbpy)] platinum complex interacting with the CGTACG hexamer== | ||
<StructureSection load='6f3c' size='340' side='right'caption='[[6f3c]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6f3c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F3C FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PT9:[Pt(H2bapbpy)]+platinum'>PT9</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f3c OCA], [http://pdbe.org/6f3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f3c RCSB], [http://www.ebi.ac.uk/pdbsum/6f3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f3c ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through pi-pi stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure. | |||
Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.,van Rixel VHS, Busemann A, Wissingh MF, Hopkins SL, Siewert B, van de Griend C, Siegler MA, Marzo T, Papi F, Ferraroni M, Gratteri P, Bazzicalupi C, Messori L, Bonnet S Angew Chem Int Ed Engl. 2019 May 2. doi: 10.1002/anie.201814532. PMID:31046177<ref>PMID:31046177</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6f3c" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Bazzicalupi, C]] | [[Category: Bazzicalupi, C]] | ||
[[Category: Ferraroni, M]] | [[Category: Ferraroni, M]] | ||
[[Category: Gratteri, P]] | [[Category: Gratteri, P]] | ||
[[Category: Papi, F]] | [[Category: Papi, F]] | ||
[[Category: Dna]] | |||
[[Category: Drug-dna complex]] | |||
[[Category: Four-way junction]] | |||
Latest revision as of 09:06, 29 May 2019
The cytotoxic [Pt(H2bapbpy)] platinum complex interacting with the CGTACG hexamerThe cytotoxic [Pt(H2bapbpy)] platinum complex interacting with the CGTACG hexamer
Structural highlights
Publication Abstract from PubMedFour-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through pi-pi stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure. Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.,van Rixel VHS, Busemann A, Wissingh MF, Hopkins SL, Siewert B, van de Griend C, Siegler MA, Marzo T, Papi F, Ferraroni M, Gratteri P, Bazzicalupi C, Messori L, Bonnet S Angew Chem Int Ed Engl. 2019 May 2. doi: 10.1002/anie.201814532. PMID:31046177[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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