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Creatine Kinase: Difference between revisions

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<StructureSection load='1crk' size='350' side='right' scene='34/345515/Cv/1' caption='Crystal Structure of mitochondrial Creatine Kinase complex with phosphate [[1crk]]'>
<StructureSection load='1crk' size='350' side='right' scene='34/345515/Cv/1' caption='Crystal Structure of mitochondrial Creatine Kinase complex with phosphate [[1crk]]'>
__TOC__
== Function ==


[[Creatine Kinase]] (CK, EC 2.7.3.2), an enzyme important for energy metabolism in cells of high and fluctuating energy requirements, catalyses the reversible transfer of a phosphoryl goup from phosphocreatine to ADP. We have solved the structure of the octameric mitochondrial isoform, Mib-CK, which is located in the intermembrane compartment and along the cristae membranes. Mib-CK consumes ATP produced in the mitochondria for the production of phosphocreatine, which is then exported into the cytosol for fast regeneration of ATP by the cytosolic CK isoforms. The octamer has 422 point-group symmetry, and appears as a cube of side length 93 angstrom with a channel 20 angstrom wide extending along the four-fold axis. Positively charged amino acids at the four-fold faces of the octamer possibly interact with negatively charged mitochondrial membranes.  
[[Creatine Kinase]] (CK, EC 2.7.3.2), an enzyme important for energy metabolism in cells of high and fluctuating energy requirements, catalyses the reversible transfer of a phosphoryl goup from phosphocreatine to ADP. We have solved the structure of the octameric mitochondrial isoform, Mib-CK, which is located in the intermembrane compartment and along the cristae membranes. Mib-CK consumes ATP produced in the mitochondria for the production of phosphocreatine, which is then exported into the cytosol for fast regeneration of ATP by the cytosolic CK isoforms. The octamer has 422 point-group symmetry, and appears as a cube of side length 93 angstrom with a channel 20 angstrom wide extending along the four-fold axis. Positively charged amino acids at the four-fold faces of the octamer possibly interact with negatively charged mitochondrial membranes.  
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</StructureSection>
</StructureSection>
==3D structures of creatine kinase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Creatine kinase - brain
**[[3drb]], [[3dre]], [[3b6r]] – hB-CK β chain – human<br />
**[[4q2r]] - bB-CK β chain – bovine<br />
**[[1qh4]] – cB-CK - chicken
*Creatine kinase – mitochondria
**[[4z9m]], [[1qk1]] – hMIB-CK<br />
**[[1crk]] – cMIB-CK
*Creatine kinase – muscle
**[[1i0e]] – hM-CK<br />
**[[2crk]] - rM-CK – rabbit<br />
**[[1u6r]] – rM-CK (mutant)<br />
**[[1vrp]] – M-CK + creatine derivative – ''Torpedo californica''
*Creatine kinase – retinal
**[[1g0w]] – bCK
}}


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Student, David Canner, Michal Harel, Alexander Berchansky
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