CD3: Difference between revisions
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<StructureSection load='1sy6' size=' | <StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'> | ||
== Function == | == Function == | ||
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref> | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref><ref>PMID:15136729</ref> | ||
*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]). | *<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]). | ||
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Drugs which bind to CD3 are tested as immunorepressants. | Drugs which bind to CD3 are tested as immunorepressants. | ||
==3D structures of CD3== | ==3D structures of CD3== | ||
[[CD3 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Latest revision as of 12:10, 30 April 2019
FunctionCD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). [1][2]
RelevanceDrugs which bind to CD3 are tested as immunorepressants. 3D structures of CD3
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ReferencesReferences
- ↑ Berry R, Headey SJ, Call MJ, McCluskey J, Tregaskes CA, Kaufman J, Koh R, Scanlon MJ, Call ME, Rossjohn J. Structure of the chicken CD3epsilondelta/gamma heterodimer and its assembly with the alphabetaT cell receptor. J Biol Chem. 2014 Mar 21;289(12):8240-51. doi: 10.1074/jbc.M113.544965. Epub 2014, Jan 31. PMID:24488493 doi:http://dx.doi.org/10.1074/jbc.M113.544965
- ↑ Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J. Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729 doi:10.1073/pnas.0402295101