CD3: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
+<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
 == Function ==
-'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM).  <ref>PMID:24488493</ref>
+'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM).  <ref>PMID:24488493</ref><ref>PMID:15136729</ref>
 *<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).
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 Drugs which bind to CD3 are tested as immunorepressants.
-<ref>PMID:15136729</ref>
-</StructureSection>
 ==3D structures of CD3==
+[[CD3 3D structures]]
+</StructureSection>
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CD3 ε chain
-**[[1a81]] – hCD3 ITAM + Syk kinase – human <BR />
-**[[2jxb]] – hCD3 domain SH3-1<br />
-**[[2k4f]] – mCD3 ITAM – mouse - NMR <BR />
-**[[3r08]] – mCD3 extracellular domain + antibody<BR />
-**[[2mim]] – CD3 – chicken<br />
-*CD3 εγ dimer
-**[[1jbj]] – hCD3 extracellular domain - NMR<BR />
-**[[1sy6]] – hCD3 extracellular domain + antibody<BR />
-*CD3 εδ dimer
-**[[1xiw]] – hCD3 extracellular domain + antibody<BR />
-**[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR />
-*CD3 ζ chain
-**[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR />
-**[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR />
-**[[2hac]] – hCD3 transmembrane domain - NMR<BR />
-}}
 == References ==
 <references/>
 [[Category: Topic Page]]