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| <StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'> | | <StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'> |
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| '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.
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| <scene name='55/551236/Cv/2'>Human CD3 extracellular domain complex with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).<ref>PMID:15136729</ref>
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| </StructureSection>
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| ==3D structures of CD3== | | == Function == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM). <ref>PMID:24488493</ref><ref>PMID:15136729</ref> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| | *<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]). |
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| *CD3 ε chain
| | == Relevance == |
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| **[[1a81]] – hCD3 ITAM + Syk kinase – human <BR />
| | Drugs which bind to CD3 are tested as immunorepressants. |
| **[[2jxb]] – hCD3 domain SH3-1<br />
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| **[[2k4f]] – mCD3 ITAM – mouse - NMR <BR />
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| **[[3r08]] – mCD3 extracellular domain + antibody<BR />
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| **[[2mim]] – CD3 – chicken<br />
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| *CD3 εγ dimer
| | ==3D structures of CD3== |
| | | [[CD3 3D structures]] |
| **[[1jbj]] – hCD3 extracellular domain - NMR<BR />
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| **[[1sy6]] – hCD3 extracellular domain + antibody<BR />
| | </StructureSection> |
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| *CD3 εδ dimer
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| **[[1xiw]] – hCD3 extracellular domain + antibody<BR />
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| **[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR />
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| *CD3 ζ chain
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| **[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR />
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| **[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR />
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| **[[2hac]] – hCD3 transmembrane domain - NMR<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category: Topic Page]] | | [[Category: Topic Page]] |