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<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry [[1sy6]])' scene=''>
<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
 
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM).  Drugs which bind to CD3 are tested as immunorepressants.


==3D structures of CD3==
== Function ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM).  <ref>PMID:24488493</ref><ref>PMID:15136729</ref>
*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).


'''CD3 ε chain'''
== Relevance ==


[[1a81]] – hCD3 ITAM + Syk kinase – human <BR />
Drugs which bind to CD3 are tested as immunorepressants.
[[2jxb]] – hCD3 domain SH3-1<br />
[[2k4f]] – mCD3 ITAM – mouse - NMR <BR />
[[3r08]] – mCD3 extracellular domain + antibody<BR />


'''CD3 εγ dimer'''
==3D structures of CD3==
 
[[CD3 3D structures]]
[[1jbj]] – hCD3 extracellular domain - NMR<BR />
[[1sy6]] – hCD3 extracellular domain + antibody<BR />
</StructureSection>
 
'''CD3 εδ dimer'''
 
[[1xiw]] – hCD3 extracellular domain + antibody<BR />
[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR />
 
'''CD3 ζ chain'''
 
[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR />
[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR />
[[2hac]] – hCD3 transmembrane domain - NMR<BR />


== References ==
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

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Michal Harel, Alexander Berchansky
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