CD3: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD2 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry [[1sy6]])' scene=''>
+<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
-'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM).  Drugs which bind to CD3 are tested as immunorepressants.
-==3D structures of CD3==
+== Function ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single Immunorecetor Tyrosine-based Activation Motif (ITAM).  <ref>PMID:24488493</ref><ref>PMID:15136729</ref>
+*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).
-'''CD2 ε chain'''
+== Relevance ==
-[[1a81]] – hCD2 ITAM + Syk kinase – human <BR />
+Drugs which bind to CD3 are tested as immunorepressants.
-[[2k4f]] – mCD2 ITAM – mouse - NMR <BR />
-[[3r08]] – mCD2 extracellular domain + antibody<BR />
-'''CD2 εγ dimer'''
+==3D structures of CD3==
+[[CD3 3D structures]]
-[[1jbj]] – hCD2 extracellular domain - NMR<BR />
-[[1sy6]] – hCD2 extracellular domain + antibody<BR />
+</StructureSection>
-'''CD2 εδ dimer'''
-[[1xiw]] – hCD2 extracellular domain + antibody<BR />
-[[1xmw]] – mCD2 extracellular domain ε/sCD2 extracellular domain δ – sheep<BR />
-'''CD2 ζ chain'''
-[[1ygr]], [[2oq1]] – hCD2 ITAM + CD45 protein tyrosine phosphatase <BR />
+== References ==
-[[3ik5]], [[3ioz]] – hCD2 ITAM + NEF<BR />
+<references/>
-[[2hac]] – hCD2 transmembrane domain - NMR<BR />
+[[Category: Topic Page]]