CCA-adding enzyme: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='3ovs' size='450' side='right' caption='Structure of CCA-adding enzyme complex with tRNA 34-mer, CTP, sulfate, ethanediol and Ca+2 ion (green) (PDB entry [[3ovs]])' scene='55/551188/Cv/1'>
+<StructureSection load='3ovs' size='350' side='right' caption='Structure of CCA-adding enzyme complex with tRNA 34-mer, CTP, sulfate, ethanediol and Ca+2 ion (green) (PDB entry [[3ovs]])' scene='55/551188/Cv/1'>
-'''CCA-adding enzyme''' (CAE) builds or repairs the trinucleotice CCA at the 3’ end of tRNA.  CAE has one active site which is capable of binding CTP and ATP in a specific sequence.  In the bacteria Aquifex aeolicus, CAE consists of 2 subunits.  One specific for CTP and the other for ATP.  CAE builds the CCA without a genetic template.
+'''CCA-adding enzyme''' (CAE) builds or repairs the trinucleotice CCA at the 3’ end of tRNA.  CAE has one active site which is capable of binding CTP and ATP in a specific sequence.  In the bacteria Aquifex aeolicus, CAE consists of 2 subunits.  One specific for CTP and the other for ATP.  CAE builds the CCA without a genetic template.<ref>PMID:15295590</ref>
-<scene name='55/551188/Cv/2'>Structure of CCA-adding enzyme complex with tRNA 34-mer, CTP, ethanediol and Ca+2 ion</scene>.
+*<scene name='55/551188/Cv/4'>CCA-adding enzyme complex with tRNA, CTP, ethanediol and Ca+2 ion</scene> (PDB entry [[3ovs]]).
-</StructureSection>
+*<scene name='55/551188/Cv/5'>Ca+2 coordination site of CCA-adding enzyme</scene> (PDB entry [[3ovs]]).<ref>PMID:21071662</ref>
 ==3D structures of CCA-adding enzyme==
+[[CCA-adding enzyme 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CCA-adding enzyme
-**[[1miv]] – BsCAE – ''Bacillus stearothermophilus''<BR />
-**[[1uet]], [[1r8a]] – AfCAE – ''Archaeoglobus fulgidus''<BR />
-**[[1ou5]], [[4x4w]] – hCAE – human<br />
-*CCA-adding enzyme binary complex with nucleotide
-**[[1miw]] – BsCAE + ATP<BR />
-**[[1uev]], [[1r8b]] – AfCAE + ATP<BR />
-**[[1miy]] – BsCAE + CTP<BR />
-**[[1ueu]], [[1r89]] – AfCAE + CTP<BR />
-**[[1r8c]] – AfCAE + UTP<BR />
-*CCA-adding enzyme binary complex with tRNA
-**[[2dr5]] – AfCAE + tRNA 32-mer<BR />
-**[[2dr7]], [[2zh1]], [[2zh7]], [[2zh9]], [[4x4q]], [[4x4t]], [[4x4u]] – AfCAE + tRNA 33-mer<BR />
-**[[2dr9]], [[2zh2]], [[2zh3]], [[2zh4]], [[2zh5]], [[2zh8]], [[2zhb]] – AfCAE + tRNA 34-mer<BR />
-**[[2drb]], [[3ouy]], [[4x4p]] – AfCAE + tRNA 35-mer<BR />
-*CCA-adding enzyme ternary complex with nucleotide and tRNA
-**[[1sz1]] – AfCAE + GTP + UMP + CMP + tRNA<BR />
+== References ==
-**[[1tfw]] – AfCAE + ATP + tRNA 3’ end<BR />
+<references/>
-**[[1tfy]] – AfCAE + CTP + tRNA 3’ end<BR />
-**[[2dr8]], [[2zha]], [[4x4s]] – AfCAE + CTP + tRNA 33-mer<BR />
-**[[4x4r]], [[4x4v]] – AfCAE + AMPCPP + tRNA 33-mer<BR />
-**[[4x4n]] – AfCAE + GTP + tRNA 33-mer<BR />
-**[[2dra]], [[2zh6]], [[3ov7]], [[4x4o]] – AfCAE + ATP + tRNA 34-mer<BR />
-**[[3ova]] – AfCAE + ATP derivative + tRNA 34-mer<BR />
-**[[2dvi]], [[3ovs]] – AfCAE + CTP + tRNA 34-mer<BR />
-**[[3ovb]] – AfCAE + ATP + tRNA 35-mer<BR />
-}}
 [[Category:Topic Page]]