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| == Structural highlights == | | == Structural highlights == |
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| Like in the AChE structure, BChE active site is located at the bottom of a ca. 20A deep gorge. The <scene name='39/399020/Cv/4'>active site of BChE</scene> is similar to that of AChE. <ref>PMID:12869558</ref> The differences are noticed in the lining of the gorge were some of the aromatic residues in AChE are substituted by hydrophobic ones and in the active site acyl-binding pocket where 2 Phe residues are replaced by Leu and Val in BChE. | | Like in the AChE structure, BChE active site is located at the bottom of a ca. 20A deep gorge. The <scene name='39/399020/Cv/6'>active site of BChE</scene> is similar to that of AChE. <ref>PMID:12869558</ref> Water molecule is shown as red sphere. The differences are noticed in the lining of the gorge were some of the aromatic residues in AChE are substituted by hydrophobic ones and in the active site acyl-binding pocket where 2 Phe residues are replaced by Leu and Val in BChE. |
| </StructureSection>
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| ==3D structures of BChE== | | ==3D structures of BChE== |
| | [[Butyrylcholinesterase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * hBChE - Apo human
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| **[[2pm8]], [[1p0i]] - hBChE - human <br />
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| **[[2xmb]] – hBChE (mutant)+SO4<br />
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| **[[2xmc]] - hBChE (mutant)+F <br />
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| **[[4aqd]] - hBChE (fully glycosylated)
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| * BChE+OP irreversible inhibitors, including nerve agents and insecticides
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| **[[3djy]], [[3dkk]] - hBChE+tabun <br />
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| **[[2wid]], [[2wif]] - hBChE+Tabun analogue TA1 <br />
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| **[[2wsl]], [[2wig]] – hBChE+Tabun analogue TA4 <br />
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| **[[2wil]], [[2wij]] - hBChE+Tabun analogue TA5 <br />
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| **[[2wik]] - hBChE+Tabun analogue TA6 <br />
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| **[[1xlw]] - hBChE+echothiophate <br />
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| **[[1xmd]], [[2xmd]] – hBChE (mutant)+echothiophate<br />
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| **[[1p0q]] - hBChE+soman <br />
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| **[[1xlu]] - hBChE+Di-Isopropyl-Phosphoro-Fluoridate (DFP)<br />
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| **[[2xmg]] - hBChE (mutant)+VX<br />
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| **[[1xlv]] – hBChE+ethyl dihydrogen phosphate<br />
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| **[[2y1k]], [[4bbz]] - hBChE (mutant) + CBDP <br />
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| **[[4b0p]], [[4b0o]] - hBChE (Aged) + pyridinium derivative<br />
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| **[[4axb]] – hBChE (aged) + 2-PAM
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| * BChE+inhibitor binding at surface of the protein (far from the active site)
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| **[[2j4c]] – hBChE+ HgCl2 <br />
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| * BChE + substrate analogues mimicking the binding of the substrate butyrylcholine
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| **[[1p0m]] - hBChE+choline <br />
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| **[[1p0p]] - hBChE+butyrylthiocholine<br />
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| **[[3o9m]] - hBChE + benzoic acid<br />
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| **[[1eho]], [[1ehq]], [[1kcj]] – hBChE + cocaine - model<br />
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| **[[4bds]] – hBChE + tacrine<br />
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| }}
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| ==Additional Resources== | | ==Additional Resources== |
| For additional information, see: [[Alzheimer's Disease]] | | For additional information, see: [[Alzheimer's Disease]] |