Bungarotoxin: Difference between revisions

Latest revision as of 11:21, 18 April 2019

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.

α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin.
β-BGT binds to the presynaptic terminal causing release of acetylcholine.
γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor.
κ-BGT binds weakly to the nicotinic acetylcholine receptor.

For toxins in Proteopedia see Toxins.

in α-Bungarotoxin (PDB code 1hc9).^[1] Water molecule shown as red sphere.

3D Structures of Bungarotoxin

Bungarotoxin 3D structures

α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996

Alpha-bungarotoxin

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel

[1] Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996

[1]

@@ Line 1: / Line 1: @@
-<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/2' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)'>
+<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/5' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code [[1hc9]])'>
 [[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br />
 *  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br />
@@ Line 6: / Line 6: @@
 *  '''κ-BGT'''  binds weakly to the nicotinic acetylcholine receptor. <br />
 For toxins in Proteopedia see [[Toxins]].
-</StructureSection>
-== 3D Structures of Bungarotoxin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* Bungarotoxin
+<scene name='42/423360/Cv/4'>Iod coordination site</scene> in α-Bungarotoxin (PDB code [[1hc9]]).<ref>PMID:11683996</ref> Water molecule shown as red sphere.
-**[[2abx]] – α-BGT <br />
+== 3D Structures of Bungarotoxin ==
-**[[1kfh]], [[1ik8]], [[1ikc]], [[1idi]], [[1idl]], [[2nbt]] – α−BGT – NMR<br />
+[[Bungarotoxin 3D structures]]
-**[[1bun]] - β2-BGT<br />
-**[[1mr6]] – γ-BGT – NMR<br />
-**[[1kba]] – κ-BGT<br />
-* BGT+binding peptide
+</StructureSection>
-**[[1l4w]], [[1ljz]], [[1kc4]], [[1kl8]], [[1jbd]], [[1haa]], [[1haj]], [[1idg]], [[1idh]], [[1hoy]], [[1bxp]], [[1abt]], [[1rgj]], [[2btx]] – α-BGT+AChR peptide - NMR<br />
-**[[1hc9]] - α-BGT+AChR peptide<br />
-* BGT+ AChR subunit
-**[[2qc1]] – α-BGT+mAChR α subunit <br />
-**[[4hqp]] - α−BGT+ AChR α7 subunit<br />
-**[[4uy2]] - α−BGT+ AChR α9 subunit<br />
-}}
 == References ==
+<references/>
 [[Alpha-bungarotoxin]]
 [[Category:Topic Page]]

Bungarotoxin: Difference between revisions

Latest revision as of 11:21, 18 April 2019

3D Structures of Bungarotoxin

ReferencesReferences

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