Bungarotoxin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel

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-{{STRUCTURE_2abx|  PDB=2abx  | SIZE=400| SCENE=Bungarotoxin/Cv/1 |right|CAPTION=α-Bungarotoxin dimer [[2abx]] }}
+<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/5' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code [[1hc9]])'>
+[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br />
+*  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br />
+*  '''β-BGT'''  binds  to the presynaptic terminal causing release of acetylcholine.<br />
+*  '''γ-BGT'''  inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor. <br />
+*  '''κ-BGT'''  binds weakly to the nicotinic acetylcholine receptor. <br />
+For toxins in Proteopedia see [[Toxins]].
-[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].  '''β-BGT'''  binds  to the presynaptic terminal causing release of acetylcholine.   For toxins in Proteopedia see [[Toxins]].
+<scene name='42/423360/Cv/4'>Iod coordination site</scene> in α-Bungarotoxin (PDB code [[1hc9]]).<ref>PMID:11683996</ref> Water molecule shown as red sphere.
 == 3D Structures of Bungarotoxin ==
+[[Bungarotoxin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-=== Bungarotoxin ===
+</StructureSection>
-[[2abx]] – α-BGT <br />
+== References ==
-[[1kfh]], [[1ik8]], [[1ikc]], [[1idi]], [[1idl]], [[2nbt]] – α-BGT - NMR<br />
+<references/>
-[[1bun]] - β2-BGT<br />
-[[1mr6]] – γ-BGT – NMR<br />
-[[1kba]] – κ-BGT<br />
-=== BGT+binding peptide ===
-[[1l4w]], [[1ljz]], [[1kc4]], [[1kl8]], [[1jbd]], [[1haa]], [[1haj]], [[1idg]], [[1idh]], [[1hoy]], [[1bxp]], [[1abt]], [[1rgj]], [[2btx]] – α-BGT+AChR peptide - NMR<br />
-[[1hc9]] - α-BGT+AChR peptide<br />
-=== BGT+ AChR subunit ===
-[[2qc1]] – α-BGT+mAChR a subunit <br />
-[[4hqp]] - α−BGT+ AChR a7 subunit<br />
+[[Alpha-bungarotoxin]]
 [[Category:Topic Page]]