Bungarotoxin: Difference between revisions

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[[Image:2abx.png|left|200px|thumb|Crystal Structure of α-Bungarotoxin [[2abx]]]]
<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/5' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code [[1hc9]])'>
{{STRUCTURE_2abx| PDB=2abx | SIZE=400| SCENE=Bungarotoxin/Cv/1 |right|CAPTION=α-Bungarotoxin [[2abx]] }}
[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br />
*  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br />
*  '''β-BGT''' binds to the presynaptic terminal causing release of acetylcholine.<br />
*  '''γ-BGT'''  inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor. <br />
*  '''κ-BGT'''  binds weakly to the nicotinic acetylcholine receptor. <br />
For toxins in Proteopedia see [[Toxins]].


[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.  α-BGT  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].  β-BGT  binds  to the presynaptic terminal causing release of acetylcholine. The images at the left and at the right correspond to one representative Bungarotoxin , ''i.e.'' the crystal structure of α-Bungarotoxin ([[2abx]]). For toxins in Proteopedia see [[Toxins]].
<scene name='42/423360/Cv/4'>Iod coordination site</scene> in α-Bungarotoxin (PDB code [[1hc9]]).<ref>PMID:11683996</ref> Water molecule shown as red sphere.
 
 
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== 3D Structures of Bungarotoxin ==  
== 3D Structures of Bungarotoxin ==  
 
[[Bungarotoxin 3D structures]]  
 
 
=== Bungarotoxin ===
 
 
[[2abx]] – α-BGT <br />
[[1kfh]], [[1ik8]], [[1ikc]], [[1idi]], [[1idl]], [[2nbt]] – α-BGT - NMR<br />
[[1bun]] - β2-BGT<br />
[[1mr6]] – γ-BGT – NMR<br />
[[1kba]] – κ-BGT<br />
 
 
=== BGT+binding peptide ===
 
 
[[1l4w]], [[1ljz]], [[1kc4]], [[1kl8]], [[1jbd]], [[1haa]], [[1haj]], [[1idg]], [[1idh]], [[1hoy]], [[1bxp]], [[1abt]], [[1rgj]], [[2btx]] – α-BGT+AChR peptide - NMR<br />
[[1hc9]] - α-BGT+AChR peptide<br />
 
=== BGT+ AChR subunit ===
 


[[2qc1]] – α-BGT+mAChR a subunit <br />
</StructureSection>


== References ==
<references/>


[[Alpha-bungarotoxin]]
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 11:21, 18 April 2019

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.

  • α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin.
  • β-BGT binds to the presynaptic terminal causing release of acetylcholine.
  • γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor.
  • κ-BGT binds weakly to the nicotinic acetylcholine receptor.

For toxins in Proteopedia see Toxins.

in α-Bungarotoxin (PDB code 1hc9).[1] Water molecule shown as red sphere.

3D Structures of Bungarotoxin

Bungarotoxin 3D structures


α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996

Alpha-bungarotoxin

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel
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