Bungarotoxin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel

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-[[Image:2abx.png|left|200px|thumb|Crystal Structure of α-Bungarotoxin [[2abx]]]]
+<StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/5' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code [[1hc9]])'>
-{{STRUCTURE_2abx|  PDB=2abx  | SIZE=300| SCENE=Bungarotoxin/Cv/1 |right|CAPTION=α-Bungarotoxin [[2abx]] }}
+[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br />
+*  '''α-BGT'''  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br />
+*  '''β-BGT'''  binds  to the presynaptic terminal causing release of acetylcholine.<br />
+*  '''γ-BGT'''  inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor. <br />
+*  '''κ-BGT'''  binds weakly to the nicotinic acetylcholine receptor. <br />
+For toxins in Proteopedia see [[Toxins]].
-[[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT),  β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.  α-BGT  binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. β-BGT  binds  to the presynaptic terminal causing release of acetylcholine. The images at the left and at the right correspond to one representative Bungarotoxin , ''i.e.'' the crystal structure of α-Bungarotoxin ([[2abx]]).
+<scene name='42/423360/Cv/4'>Iod coordination site</scene> in α-Bungarotoxin (PDB code [[1hc9]]).<ref>PMID:11683996</ref> Water molecule shown as red sphere.
-{{TOC limit|limit=2}}
 == 3D Structures of Bungarotoxin ==
+[[Bungarotoxin 3D structures]]
-=== Bungarotoxin ===
-[[2abx]] – α-BGT <br />
-[[1kfh]], [[1ik8]], [[1ikc]], [[1idi]], [[1idl]], [[2nbt]] – α-BGT - NMR<br />
-[[1mr6]] – γ-BGT – NMR<br />
-[[1kba]] – κ-BGT<br />
-=== BGT+binding peptide ===
-[[1rji]],  [[1l4w]], [[1ljz]], [[1kc4]], [[1kl8]], [[1hc9]], [[1jbd]], [[1haa]], [[1haj]], [[1idg]], [[1idh]], [[1hoy]], [[1bxp]], [[1btx]], [[1abt]] – α-BGT+AChR peptide - NMR<br />
-=== BGT+ AChR subunit ===
+</StructureSection>
+== References ==
+<references/>
-[[2qc1]] – α-BGT+mAChR a subunit <br />
+[[Alpha-bungarotoxin]]
+[[Category:Topic Page]]