Beta-lactoglobulin: Difference between revisions

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<StructureSection load='1BEB' size='450' side='right' scene='Molecular_Playground/BLG/Blgscene/1' caption='Bovine β-lactoglobulin (PDB code [[1beb]])'>
<StructureSection load='1BEB' size='350' side='right' scene='Molecular_Playground/BLG/Blgscene/1' caption='Bovine β-lactoglobulin (PDB code [[1beb]])'>
'''β-lactoglobulin''' is a [[CBI Molecules]] being studied in the  <span class="plainlinks">[http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program]</span> at UMass Amherst and on display at the <span class="plainlinks">[http://www.molecularplayground.org/ Molecular Playground]</span>.
'''β-lactoglobulin''' <ref>PMID:15259212</ref> is a [[CBI Molecules]] being studied in the  <span class="plainlinks">[http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program]</span> at UMass Amherst and on display at the <span class="plainlinks">[http://www.molecularplayground.org/ Molecular Playground]</span>.
{{Clear}}
{{Clear}}
=== BLG as studied in the Dubin Lab ===
=== BLG as studied in the Dubin Lab ===


'''β-lactoglobulin''' is a dimeric protein that exists in two forms.  BLG A and BLG B, which differ by two mutations, one of which is a non-charged residue being replaced by an Aspartic Acid, which at relevant pH values is negatively charged.  The result is a protein that exists in two isoforms, which differ by two negative charges (one per monomer).
'''β-lactoglobulin''' is a dimeric protein that exists in two forms.  BLG A and BLG B, which differ by two mutations, one of which is a non-charged residue being replaced by an Aspartic Acid, which at relevant pH values is negatively charged.  The result is a protein that exists in two isoforms, which differ by two negative charges (one per monomer).  
 
The differences between these two forms significantly augment the electrostatic potential, making BLG A & BLG B an ideal system for studying the interaction of a protein with a polyelectrolyte. More details in [[Molecular Playground/BLG]].
 
==3D structures of beta-lactoglobulin==
[[Beta-lactoglobulin 3D structures]]


The differences between these two forms significantly augment the electrostatic potential, making BLG A & BLG B an ideal system for studying the interaction of a protein with a polyelectrolyte.  More details in [[Molecular Playground/BLG]].
</StructureSection>
</StructureSection>
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__NOTOC__


    
    
==3D structures of beta-lactoglobulin==
== References ==
 
<references/>
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*β-lactoglobulin
 
**[[1beb]], [[1bsy]], [[2blg]], [[3blg]], [[1dv9]], [[1qg5]], [[1b8e]], [[2akq]], [[2q2m]], [[2q2p]], [[2q39]], [[3npo]], [[3ph5]], [[3ph6]], [[4lzu]], [[4lzv]] – bBlac – bovine<br />
**[[1bsq]], [[1cj5]], [[1uz2]] – bBlac (mutant) <br />
**[[3kza]] – bBlac/hBlac - horse<br />
**[[1exs]] – Blac – pig<br />
**[[1yup]] – Blac – reindeer<br />
**[[4ck4]], [[4nli]], [[4nlj]] – Blac – sheep<br />
**[[4omw]], [[4omx]], [[4tlj]] – Blac – goat<br />
 
*β-lactoglobulin complexes
 
**[[1b0o]], [[3uew]] – bBlac + palmitate<br />
**[[1bso]] – bBlac + bromododecanoic acid<br />
**[[3nq3]], [[3nq9]], [[3qzj]], [[3qzk]], [[3uex]] – bBlac + fatty acid<br />
**[[3ueu]], [[4ib6]] - bBlac + lauric acid<br />
**[[4dq3]] - bBlac + oleic acid<br />
**[[4dq4]] - bBlac + linoleic acid<br />
**[[3uev]] - bBlac + myristic acid<br />
**[[1gx9]], [[1gx8]] – bBlac + retinoic acid<br />
**[[1gxa]] - bBlac + retinoic acid + palmitate<br />
**[[4gny]], [[4ib8]], [[4iba]] - bBlac + dodecyl sulfate<br />
**[[4ib7]], [[4ib9]] - bBlac + dodecyltrimethylammonium<br />
**[[4kii]] - bBlac + dodecanamide derivative<br />
**[[2gj5]] – bBlac + vitamin D3<br />
**[[2r56]] – bBlac + antibody
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky