Beta-lactoglobulin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<Structure load='1b0o' size='400' frame='true' align='right' caption=' Bovine beta-lactoglobulin complex with palmitate [[1b0o]]' scene= />
+<StructureSection load='1BEB' size='350' side='right' scene='Molecular_Playground/BLG/Blgscene/1' caption='Bovine β-lactoglobulin (PDB code [[1beb]])'>
+'''β-lactoglobulin''' <ref>PMID:15259212</ref> is a [[CBI Molecules]] being studied in the  <span class="plainlinks">[http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program]</span> at UMass Amherst and on display at the <span class="plainlinks">[http://www.molecularplayground.org/ Molecular Playground]</span>.
-β-lactoglobulin is a [[CBI Molecules]] being studied in the  <span class="plainlinks">[http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program]</span> at UMass Amherst and on display at the <span class="plainlinks">[http://www.molecularplayground.org/ Molecular Playground]</span>.
+{{Clear}}
 === BLG as studied in the Dubin Lab ===
-<Structure load='1BEB' size='400' frame='true' align='right' caption='BLG A and BLG B are isoforms that differ by 2 charge units [[1beb]]' scene='Molecular_Playground/BLG/Blgscene/1' />
+'''β-lactoglobulin''' is a dimeric protein that exists in two forms.  BLG A and BLG B, which differ by two mutations, one of which is a non-charged residue being replaced by an Aspartic Acid, which at relevant pH values is negatively charged.  The result is a protein that exists in two isoforms, which differ by two negative charges (one per monomer).
-'''β-lactoglobulin''' is a dimeric protein that exists in two forms.  BLG A and BLG B, which differ by two mutations, one of which is a non-charged residue being replaced by an Aspartic Acid, which at relevant pH values is negatively charged.  The result is a protein that exists in two isoforms, which differ by two negative charges (one per monomer).
+The differences between these two forms significantly augment the electrostatic potential, making BLG A & BLG B an ideal system for studying the interaction of a protein with a polyelectrolyte. More details in [[Molecular Playground/BLG]].
-The differences between these two forms significantly augment the electrostatic potential, making BLG A & BLG B an ideal system for studying the interaction of a protein with a polyelectrolyte.
 ==3D structures of beta-lactoglobulin==
+[[Beta-lactoglobulin 3D structures]]
-[[1beb]], [[1bsy]], [[2blg]], [[3blg]], [[1dv9]], [[1qg5]], [[1b8e]], [[2akq]], [[2q2m]], [[2q2p]], [[2q39]], [[3npo]], [[3ph5]], [[3ph6]] – bBlac – bovine<br />
+</StructureSection>
-[[1bsq]], [[1cj5]], [[1uz2]] – bBlac (mutant) <br />
+__NOTOC__
-[[3kza]] – bBlac/hBlac - horse<br />
-[[1exs]] – Blac – pig<br />
-[[1yup]] – Blac – reindeer
-===Beta-lactoglobulin complexes===
-[[1b0o]], [[3uew]] – bBlac + palmitate<br />
-[[1bso]] – bBlac + bromododecanoic acid<br />
-[[3nq3]], [[3nq9]], [[3qzj]], [[3qzk]], [[3uex]] – bBlac + fatty acid<br />
-[[3ueu]] - bBlac + lauric acid<br />
-[[3uev]] - bBlac + myristic acid<br />
-[[1gx9]] – bBlac + retinoic acid<br />
-[[1gxa]] - bBlac + retinoic acid + palmitate<br />
-[[2gj5]] – bBlac + vitamin D3<br />
-[[2r56]] – bBlac + antibody
+== References ==
+<references/>
 [[Category:Topic Page]]