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Beta-phosphoglucomutase: Difference between revisions

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<StructureSection load='2wf5' size='340' side='right' caption='Structure of β-phosphoglucomutase complex with β-D-glucose-6-phosphate, MgF3 and Mg+2 ion (PDB code [[2wf5]]).' scene=''>
<StructureSection load='1lvh' size='350' side='right' caption='Structure of phosphorylated β-phosphoglucomutase complex with Mg+2 ion (PDB code [[1lvh]]).' scene='59/595758/Cv/14'>


== Function ==
== Function ==
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'''Beta-phosphoglucomutase''' (BPGM) catalyzes the conversion of β-D-glucose 1-phosphate to β-D-glucose 6-phosphate.  Mg+2 ion is the cofactor of the reaction and BPGM activation is achieved by Asp8 phosphorylation (D8P).  α-D-galactose-1-phosphate is an inhibitor of BPGM.  BPGM participates in sugar and starch metabolism.
'''Beta-phosphoglucomutase''' (BPGM) catalyzes the conversion of β-D-glucose 1-phosphate to β-D-glucose 6-phosphate.  Mg+2 ion is the cofactor of the reaction and BPGM activation is achieved by Asp8 phosphorylation (D8P).  α-D-galactose-1-phosphate is an inhibitor of BPGM.  BPGM participates in sugar and starch metabolism.


== Disease ==
== Structural highlights ==
 
== Relevance ==


== Structural highlights ==
BPGM structure shows the enzyme having <scene name='59/595758/Cv/9'>2 domains</scene>. A <scene name='59/595758/Cv/10'>helical cap domain</scene> and an <scene name='59/595758/Cv/11'>α/β core domain</scene>. The <scene name='59/595758/Cv/12'>active site</scene> is located in the core domain and contains a <scene name='59/595758/Cv/13'>phosphorylated Asp residue and the octahedral coordinated Mg+2 ion</scene>. <ref>PMID:12081483</ref>


== 3D Structures of β-phosphoglucomutase ==
== 3D Structures of β-phosphoglucomutase ==
[[Beta-phosphoglucomutase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*β-phosphoglucomutase
 
**[[3nas]] – BPGM – ''Bacillus subtilis''<br />
**[[4g9b]] – BPGM + Mg – ''Escherichia coli''<br />
**[[1zol]], [[2whe]] – LlBPGM + Mg – ''Lactococcus lactis''<br />
**[[3fm9]] – LlBPGM (mutant) + Mg <br />
**[[2wfa]] – LlBPGM + BeF3 + Mg <br />
**[[1lvh]] – LlBPGM + D8P + Mg <br />
 
*β-phosphoglucomutase complex with glucophosphate derivatives
 
**[[1o03]], [[1o08]] – LlBPGM + α-D-glucose 1,6-bisphosphate + Mg <br />
**[[1z4n]], [[1z4o]] – LlBPGM + α-D-galactose-1-phosphate + Mg <br />
**[[2wf5]] – LlBPGM + β-D-glucose-6-phosphate + MgF3 + Mg <br />
**[[3zi4]] – LlBPGM + β-D-glucose-6-phosphate + ScF4 + Mg <br />
**[[2wf6]] – LlBPGM + β-D-glucose-6-phosphate + AlF4 + Mg <br />
**[[2wf7]] – LlBPGM + dideoxy-phosphono-β-D-gluco-heptopyranose + AlF4 + Mg <br />
**[[4c4r]], [[4c4s]] – LlBPGM + β-phosphonomethylene-D-glucopyranose derivative + MgF3 + Mg <br />
**[[4c4t]] – LlBPGM + β-phosphonomethylene-D-glucopyranose derivative + AlF4 + Mg <br />
**[[2wf8]] – LlBPGM + β-D-glucose-6-phosphate + α-D-glucose-1-phosphate + BeF3 + Mg <br />
**[[2wf9]] – LlBPGM + β-D-glucose-6-phosphate + α-D-glucose-6-phosphate + BeF3 + Mg <br />
}}


== References ==
== References ==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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