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Bam complex: Difference between revisions

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<StructureSection load='4n75' size='340' side='right' caption='E. coli BamA/BamB (PDB code [[4pk1]])' scene=''>
<StructureSection load='' size='340' side='right' caption='E. coli BamA barrel domain (PDB code [[4n75]])' scene='70/706705/Cv/2'>


== Function ==
== Function ==


The '''Bam''' (β-Barrel Assembly Machinery) drives the assembly of β-barrel proteins into the outer membrane of gram-negative bacteria.   
The '''Bam''' (β-Barrel Assembly Machinery) drives the assembly of β-barrel proteins into the outer membrane of gram-negative bacteria.<ref>PMID:19182809</ref>  


== Structural highlights ==
== Structural highlights ==
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*'''BamA''' contains five structurally homologous POTRA (POlypeptide TRAnslocation associated) domains.  The POTRA domain has a β-α-α-β-β conformation.  BamA barrel and at least a subset of its POTRAs are essential for viability.  BamA was found also in mitochondria and chloroplasts.<br />
*'''BamA''' contains five structurally homologous POTRA (POlypeptide TRAnslocation associated) domains.  The POTRA domain has a β-α-α-β-β conformation.  BamA barrel and at least a subset of its POTRAs are essential for viability.  BamA was found also in mitochondria and chloroplasts.<br />
*'''BamD''' is composed of multiple tetratricopeptide (TPR) repeats packed into a superhelical structure.  TPR is a motif containing 2 antiparallel α-helices.  TPRs are found in scaffold multiprotein complexes and are involved in protein-protein interactions.
*'''BamD''' is composed of multiple tetratricopeptide (TPR) repeats packed into a superhelical structure.  TPR is a motif containing 2 antiparallel α-helices.  TPRs are found in scaffold multiprotein complexes and are involved in protein-protein interactions.
</StructureSection>


== 3D Structures of Bam complex ==
== 3D Structures of Bam complex ==
[[Bam complex 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*BamA (Omp85)
 
**[[4k3b]] – BamA – ''Neisseria gonorrhoeae'' <br />
**[[4k3c]] – BamA – ''Haemophilus ducreyi'' <br />
**[[4c4v]] – EcBamA – ''Escherichia coli'' <br />
**[[4pk1]] – EcBamA/BamB <br />
**[[4n75]] – EcBamA barrel domain<br />
**[[3og5]], [[3q6b]] – EcBamA POTRA45 domain<br />
 
*BamB (Lipoprotein YFGL)
 
**[[3q7m]], [[3q7n]], [[3q7o]], [[3p1l]], [[2yms]] – EcBamB  <br />
**[[3q54]], [[3prw]], [[2yh3]] – EcBamB residues 25-392 <br />
**[[4hdj]] – BamB residues 20-380 – ''Pseudomonas aeruginosa''<br />
**[[4imm]] – BamB – ''Moraxella catarrhalis'' <br />
 
*BamC (Lipoprotein 34)
 
**[[2yh5]], [[3sns]] – EcBamC C terminal  <br />
**[[2lae]] – EcBamC C terminal - NMR <br />
**[[2yh6]] – EcBamC N terminal  <br />
**[[2laf]] – EcBamC N terminal - NMR <br />
 
*BamD (Lipoprotein YFIO)
 
**[[2yhc]], [[3q5m]] – EcBamD residues 29-245 <br />
**[[3qky]] – BamD residues 24-280 – ''Rhodothermus marinus''<br />
 
**[[3tgo]] – EcBamD residues 21-245 + lipoprotein 34<br />
 
*BamE (Small protein A)
 
**[[2yh9]] – EcBamE residues 34-113 <br />
**[[2kxx]] – EcBamE residues 21-114 - NMR <br />
**[[2km7]] – EcBamE residues 21-114 (mutant) - NMR <br />
}}


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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