ATP-dependent Clp protease adaptor protein: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(4 intermediate revisions by 3 users not shown)
Line 1: Line 1:
<StructureSection load='3o2h' size='340' side='right' caption='E. coli ClpS (deep sky blue) complex with peptide (green) (PDB code [[3o2h]])' scene='77/774064/Cv/1'>
<StructureSection load='' size='340' side='right' caption='E. coli ClpS (deep sky blue) complex with peptide (green) (PDB code [[3o2h]])' scene='77/774064/Cv/1'>




Line 8: Line 8:
== Structural highlights ==
== Structural highlights ==


ClpS His residue binds to the N-terminal Leu which is one of the N-end rule residues<ref>PMID:11931773</ref>.
<scene name='77/774064/Cv/2'>ClpS His residue binds to the N-terminal Leu which is one of the N-end rule residues</scene><ref>PMID:11931773</ref>.


</StructureSection>
== 3D Structures of ATP-dependent Clp protease adaptor protein ==
== 3D Structures of ATP-dependent Clp protease adaptor protein ==
[[ATP-dependent Clp protease adaptor protein 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>


[[3o2o]], [[3o1f]] – EcClpS – ''Escherichia coli''  <br />
[[1r6o]], [[1r6q]] – EcClpS + ClpA <br />
[[3o2b]], [[3o2h]], [[2wa9]], [[2w9r]], [[2wa8]] – EcClpS + peptide<br />
[[3gq0]] – CvClpS – ''Caulobacter vibrioides'' <br />
[[3g19]], [[3gq1]], [[3gw1]], [[3dnj]] – CvClpS + peptide<br />
[[3g1b]], [[3g3p]] – CvClpS (mutant) + peptide<br />
[[4yjm]] – AtClpS 2 – ''Agrobacterium tumefaciens'' <br />
[[4yjx]], [[4yka]] – AtClpS 2 + amino acid<br />
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:06, 25 March 2019


Function

ATP-dependent Clp protease adaptor protein (ClpS) influences the protein degradation by binding to the chaperone-protease ClpAP toward degradation of aggregated proteins[1]. Degradation susceptibility is related to N-terminal residues. It is formulated by the N-end rule[2]. In bacteria the residues are Tyr, Phe, Trp and Leu. ClpS binds these residues and delivers the protein to degradation by ClpAP[3].

Structural highlights

[4].

3D Structures of ATP-dependent Clp protease adaptor protein

ATP-dependent Clp protease adaptor protein 3D structures


E. coli ClpS (deep sky blue) complex with peptide (green) (PDB code 3o2h)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Dougan DA, Reid BG, Horwich AL, Bukau B. ClpS, a substrate modulator of the ClpAP machine. Mol Cell. 2002 Mar;9(3):673-83. PMID:11931773
  2. ↑ Varshavsky A. Discovery of cellular regulation by protein degradation. J Biol Chem. 2008 Dec 12;283(50):34469-89. doi: 10.1074/jbc.X800009200. Epub 2008, Aug 15. PMID:18708349 doi:http://dx.doi.org/10.1074/jbc.X800009200
  3. ↑ Schuenemann VJ, Kralik SM, Albrecht R, Spall SK, Truscott KN, Dougan DA, Zeth K. Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS. EMBO Rep. 2009 May;10(5):508-14. Epub 2009 Apr 17. PMID:19373253 doi:10.1038/embor.2009.62
  4. ↑ Dougan DA, Reid BG, Horwich AL, Bukau B. ClpS, a substrate modulator of the ClpAP machine. Mol Cell. 2002 Mar;9(3):673-83. PMID:11931773

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=ATP-dependent_Clp_protease_adaptor_protein&oldid=3016473"