ATP-dependent Clp protease adaptor protein: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='3o2h' size='340' side='right' caption='E. coli ClpS complex with peptide (PDB code 3o2h)' scene=''> == Function == '''ATP-dependent Clp protease adaptor pro... |
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<StructureSection load='' size='340' side='right' caption='E. coli ClpS (deep sky blue) complex with peptide (green) (PDB code [[3o2h]])' scene='77/774064/Cv/1'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''ATP-dependent Clp protease adaptor protein''' (ClpS) influences the protein degradation by binding to the chaperone-protease ClpAP toward degradation of aggregated proteins<ref>PMID:11931773</ref>. | '''ATP-dependent Clp protease adaptor protein''' (ClpS) influences the protein degradation by binding to the chaperone-protease ClpAP toward degradation of aggregated proteins<ref>PMID:11931773</ref>. Degradation susceptibility is related to N-terminal residues. It is formulated by the N-end rule<ref>PMID:18708349</ref>. In bacteria the residues are Tyr, Phe, Trp and Leu. ClpS binds these residues and delivers the protein to degradation by ClpAP<ref>PMID:19373253</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
<scene name='77/774064/Cv/2'>ClpS His residue binds to the N-terminal Leu which is one of the N-end rule residues</scene><ref>PMID:11931773</ref>. | |||
== 3D Structures of ATP-dependent Clp protease adaptor protein == | == 3D Structures of ATP-dependent Clp protease adaptor protein == | ||
[[ATP-dependent Clp protease adaptor protein 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||