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ATP Phosphoribosyl Transferase: Difference between revisions

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=='''Structure of ATP-PRTase from ''Mycobacterium tuberculosis'''==''<ref> Cho Y, Sharma, V and Sacchettini; (2003). Crystal structure of ATP phosphoribosyl transferase from ''Mycobacterium tuberculosis'', J. Biol. Chem. '''278''', 8333-8339 </ref>
'''Structure of ATP-PRTase from ''Mycobacterium tuberculosis'''''<ref> Cho Y, Sharma, V and Sacchettini; (2003). Crystal structure of ATP phosphoribosyl transferase from ''Mycobacterium tuberculosis'', J. Biol. Chem. '''278''', 8333-8339 </ref>


ATP-PRTase has three domains with an α/β fold. The C-terminal domain (domain 3), consisting of a beta sheet with four strands is flanked on one side of the sheet by two helices. The two N-terminal domains house the catalytic site in their interdomain region. Domain 1 has a central beta sheet with three helices around it whilst domain 2 has two  helices on each side of a sheet made up of four parallel strands and one anti parallel strand.  
ATP-PRTase has three domains with an α/β fold. The C-terminal domain (domain 3), consisting of a beta sheet with four strands is flanked on one side of the sheet by two helices. The two N-terminal domains house the catalytic site in their interdomain region. Domain 1 has a central beta sheet with three helices around it whilst domain 2 has two  helices on each side of a sheet made up of four parallel strands and one anti parallel strand.  
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==3D structures of ATP phosphoribosyl transferase==
==3D structures of ATP phosphoribosyl transferase==
[[ATP phosphoribosyl transferase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*ATP-PRTase HisG
**[[2vd2]] – ATP-PRTase HisG – ''Bacillus subtilis''<br />
**[[2vd3]] - ATP-PRTase HisG – ''Methanobacterium thermoautotrophicum''<br />
**[[1o63]], [[1o64]] - TmATP-PRTase HisG<br />
**[[1h3d]] - EcATP-PRTase HisG + AMP – ''Escherichia coli''<br />
**[[1q1k]] - EcATP-PRTase HisG + PR-ATP<br />
**[[1nh7]] - MtATP-PRTase HisG – ''Mycobacterium tuberculosis''<br />
**[[1nh8]] - MtATP-PRTase HisG + AMP + histidine<br />
**[[1ve4]] - ATP-PRTase HisG – ''Thermus thermophilus''<br />
*ATP-PRTase HisZ
**[[3od1]] - ATP-PRTase HisZ – ''Bacillus halodurans''<br />
**[[3rac]] – ATP-PRT HisZ – ''Alicyclobacillus acidocaldarius''
*ATP-PRTase HisG+HisZ
**[[1z7m]] - LlATP-PRTase HisG+HisZ – ''Lactococcus lactis''<br />
**[[1usy]] - TmATP-PRTase HisG+HisZ – ''Thermotoga maritima''<br />
}}
==Additional Resources==
==Additional Resources==
For additional information, see: [[Amino Acid Synthesis & Metabolism]]
For additional information, see: [[Amino Acid Synthesis & Metabolism]]

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Lawrence Sheringham Borketey, David Canner, Michal Harel, Alexander Berchansky
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