Amyloid precursor protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 * [[Human APP]]<br />
 * [[Human APP Intracellular Domain Complex with Fe65-PTB2]]<br />
-* [[Amyloid beta]].
+* [[Beta Amyloid forms Plaques]]<br />
+* [[Amyloid beta]]
 == Structural highlights ==
 The extracellular region of APP contains several domains named E1 (residues 1-189) and E2 (residues 346-551).  The E1 domain contains a growth factor-like or heparin-binding (residues 28-123) and Cu-binding (residues 124-189) subdomains.  Additional domains are: Kunitz-type protease inhibitor (residues 287-344) and Zn-binding (residues 672-687).  The Z-binding domain is involved in the oligomerizatin of APP.
-</StructureSection>
 ==3D structures of amyloid precursor protein==
+[[Amyloid precursor protein 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*APP
-**[[3nyj]], [[3nyl]], [[3umh]], [[3umi]], [[3umk]] – hAPP E2 domain – human<BR />
-**[[4pwq]], [[3ktm]] - hAPP E1 domain<br />
-**[[3ktm]] – hAPP residues 18-190<BR />
-**[[1ze7]], [[2bp4]] – hAPP zinc-binding domain – NMR<BR />
-**[[2fjz]], [[2fma]] - hAPP residues 133-189<BR />
-**[[1owt]] - hAPP residues 133-189 - NMR<BR />
-**[[5buo]] – hAPP residues 351-691<br />
-**[[1tkn]] - hAPP residues 460-569 - NMR<BR />
-**[[1mwp]], [[4pqd]] - hAPP heparin-binding domain<br />
-**[[5txd]] – hAPP residues 698-703<br />
-**[[5how]], [[5hox]], [[5hoy]] – hAPP residues 698-707 (mutant)<br />
-**[[5aef]] – hAPP residues 630-657 – Cryo EM<br />
-*hAPP β-peptide
-**[[1z0q]], [[2beg]] – hAPP β-peptide residues 1-42 – NMR<br />
-**[[5oqv]] – hAPP -peptide residues 1-42 – Cryo EM<br />
-**[[1amb]], [[1amc]] – hAPP β-peptide residues 1-28 – NMR<br />
-**[[1qcm]], [[1qyt]], [[1qwp]], [[1qxc]] – hAPP β-peptide residues 25-35 – NMR<br />
-**[[1ba4]], [[1ba6]], [[2lnq]] – hAPP β-peptide residues 1-40 – NMR<br />
-**[[1bjb]], [[1bjc]] – hAPP β-peptide residues 1-28 (mutant) – NMR<br />
-**[[5lfy]] – hAPP -peptide residues 17-26 – NMR<br />
-**[[1nmj]] – APP β-peptide residues 1-28 – rat – NMR<br />
-**[[3bae]] – hAPP β-peptide residues 1-28 + antibody<br />
-**[[3bkj]] – hAPP β-peptide residues 1-16 + antibody<br />
-**[[2roz]] – hAPP β-peptide residues 1-32 + amyloid β A4 precursor protein - NMR<br />
-**[[2wk3]] – hAPP β-peptide residues 1-42 + insulin-degrading enzyme<br />
-*Amyloid precursor protein binary complex
-**[[1ze9]] - hAPP zinc-binding domain + Zn – NMR<BR />
-**[[2fk1]], [[2fk2]], [[2fk3]], [[2fkl]] - hAPP residues 133-189 + Cu<BR />
-**[[3jti]], [[3gci]] – hAPP peptide residues 699-706 + phospholipase A2<BR />
-**[[3l81]] - hAPP peptide residues 761-767 + AP-4 complex subunit μ-1<BR />
-**[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]], [[2r0w]] - hAPP peptide residues 672-711 + antibody<BR />
-**[[2wk3]] - hAPP residues 672-713 + insulin degrading enzyme<BR />
-**[[3dxc]] - hAPP residues 739-770 + Fe65-PTB2<BR />
-**[[3dxd]], [[3dxe]] - hAPP residues 739-770 (mutant) + Fe65-PTB2<BR />
-**[[2roz]] - hAPP peptide residues 582-704 + Fe65 C terminal<BR />
-**[[2otk]] - hAPP residues 672-711 + ZAB3 affibody dimer - NMR<BR />
-**[[3l3t]] - hAPP residues 211-267 + mesotrypsin<br />
-**[[3l33]], [[5c67]] - hAPP residues 290-341 + trypsin-3 (mutant)<br />
-**[[5amb]] – hAPP residues 706-713 + angiotensin-converting enzyme<br />
-**[[5am8]] – hAPP residues 675-681 + angiotensin-converting enzyme<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]