Alpha-lytic protease: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
-<StructureSection load='1p05' size='350' side='right' caption='Structure of alpha-lytic protease complex with boronic acid inhibitor and sulfate (PDB entry [[1p05]])' scene=''>
+<StructureSection load='3pro' size='350' side='right' caption='Structure of alpha-lytic protease protease domain (green) and pro domain (magenta) complex with benzenesulfonyl fluoride (PDB entry [[3pro]])' scene='55/551214/Cv/1'>
-'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region that catalyzes the folding of the protease.  The second domain is the protease domain.
+'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease.  The second domain is the protease domain (residues 200-397).<ref>PMID:2611204</ref>
+*<scene name='55/551214/Cv/4'>ALP protease domain and pro domain complex with benzenesulfonyl fluoride</scene>. Water molecules are shown as red spheres.
+*<scene name='55/551214/Cv/5'>Benzenesulfonyl fluoride binding site</scene> (PDB entry [[3pro]]).<ref>PMID:9808037</ref>
 == 3D Structures of alpha-lytic protease ==
+[[Alpha-lytic protease 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-===ALP protease domain===
+== References ==
+<references/>
-[[2alp]], [[1p09]], [[1tal]], [[2ull]], [[1boq]], [[1ssz]], [[2h5c]], [[1ssx]] – LeALP – ''Lysobacter enzymogenes''  <BR />
+[[Category: Topic Page]]
-[[1gba]], [[1gbe]], [[1gbj]], [[3urc]], [[3urd]], [[3ure]] – LeALP (mutant)  <BR />
-[[1p01]], [[1p02]], [[1p03]], [[1p04]], [[1p05]], [[1p06]], [[1p10]], [[2lpr]], [[3lpr]], [[5lpr]], [[6lpr]], [[7lpr]], [[8lpr]], [[9lpr]], [[2h5d]] – LeALP + boronic acid inhibitor  <BR />
-[[1gbb]], [[1gbc]], [[1gbd]], [[1gbf]], [[1gbh]], [[1gbi]], [[1gbk]], [[1gbl]], [[1gbm]] – LeALP (mutant) + boronic acid inhibitor  <BR />
-[[1p11]], [[1p12]] – LeALP + phosphonate esther inhibitor  <BR />
-[[3qgj]] – LeALP + peptide  <BR />
-===ALP including pro region===
-[[2pro]], [[1qrx]] – LeALP pro region  <BR />
-[[1qq4]], [[1qrw]], [[3m7t]], [[3m7u]] – LeALP pro region (mutant) <BR />
-[[3pro]] – LeALP (mutant) + pro region  <BR />
-[[4pro]] – LeALP (mutant) + pro region (mutant) <BR />