Diphtheria toxin repressor: Difference between revisions
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<StructureSection load='1c0w' size='350' side='right' caption='Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry [[1c0w]])' scene=''> | <StructureSection load='1c0w' size='350' side='right' caption='Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry [[1c0w]])' scene='55/554905/Cv/1'> | ||
'''Diphtheria toxin repressor''' (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. The DtxR regulates the expression of high affinity iron uptake system. <ref>PMID:12675807</ref> | '''Diphtheria toxin repressor''' (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. The DtxR regulates the expression of high affinity iron uptake system. <ref>PMID:12675807</ref> | ||
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== Structural highlights == | == Structural highlights == | ||
DtxR structure contains an N-terminal domain which contains DNA-binding domain (DBD) with a helix-turn-helix motif, dimerization and metal-binding residues. | DtxR structure contains an <scene name='55/554905/Cv/7'>N-terminal domain</scene> which contains <scene name='55/554905/Cv/8'>DNA-binding domain (DBD) with a helix-turn-helix motif</scene>, dimerization and metal-binding residues. DtxR contains <scene name='55/554905/Cv/9'>2 metal binding sites</scene>. | ||
*<scene name='55/554905/Cv/10'>First metal binding site</scene>. | |||
*<scene name='55/554905/Cv/11'>Second metal binding site</scene>. | |||
A C-terminal domain folds into SH3-like conformation.<ref>PMID:10497029</ref> | |||
</StructureSection> | </StructureSection> | ||