Diphtheria toxin repressor: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
+<StructureSection load='1c0w' size='350' side='right' caption='Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry [[1c0w]])' scene='55/554905/Cv/1'>
-<StructureSection load='1c0w' size='350' side='right' caption='Structure of diphtheria toxin repressor complex with DNA and Co+2 ion (PDB entry [[1c0w]]) scene=''>
+'''Diphtheria toxin repressor''' (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment.  The DtxR regulates the expression of high affinity iron uptake system.  <ref>PMID:12675807</ref>
-'''Diphtheria toxin repressor''' (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment.  DtxR structure contains a DNA-binding domain (DBD) containing the hlix-turn-helix motif at the N-terminal, an interface domain containing the metal-binding sites and a flexible C-terminal.  The DtxR regulates the expression of high affinity iron uptake system.
+== Structural highlights ==
+DtxR structure contains an <scene name='55/554905/Cv/7'>N-terminal domain</scene> which contains <scene name='55/554905/Cv/8'>DNA-binding domain (DBD) with a helix-turn-helix motif</scene>, dimerization and metal-binding residues. DtxR contains <scene name='55/554905/Cv/9'>2 metal binding sites</scene>.
+*<scene name='55/554905/Cv/10'>First metal binding site</scene>.
+*<scene name='55/554905/Cv/11'>Second metal binding site</scene>.
+A C-terminal domain folds into SH3-like conformation.<ref>PMID:10497029</ref>
+</StructureSection>
 ==3D structures of diphtheria toxin repressor==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*DtxR
-[[1dpr]], [[1bi1]], [[1bi2]] – CdDtxR – ''Corynebacterium diphtheriae''<br />
+**[[1dpr]], [[1bi1]], [[1bi2]] – CdDtxR – ''Corynebacterium diphtheriae''<br />
-[[1g3s]], [[1g3t]], [[1p92]] – CdDtxR (mutant) <br />
+**[[1g3s]], [[1g3t]], [[1p92]] – CdDtxR (mutant) <br />
-[[1bym]], [[1qvp]], [[1qw1]] – CdDtxR C terminal - NMR<br />
+**[[1bym]], [[1qvp]], [[1qw1]] – CdDtxR C terminal - NMR<br />
-'''DtxR complex with metal'''
+*DtxR complex with metal
-[[2dtr]] – CdDtxR + Co<br />
+**[[2dtr]] – CdDtxR + Co<br />
-[[1bi3]], [[1bi0]] – CdDtxR + Zn<br />
+**[[1bi3]], [[1bi0]] – CdDtxR + Zn<br />
-[[1fwz]], [[1g3y]] – CdDtxR (mutant) + Zn<br />
+**[[1fwz]], [[1g3y]] – CdDtxR (mutant) + Zn<br />
-[[2tdx]], [[1xcv]], [[2qq9]], [[2qqa]], [[2qqb]], [[3glx]] – CdDtxR (mutant) + Ni <br />
+**[[2tdx]], [[1xcv]], [[2qq9]], [[2qqa]], [[2qqb]], [[3glx]] – CdDtxR (mutant) + Ni <br />
-[[1g3w]] – CdDtxR (mutant) + Cd<br />
+**[[1g3w]] – CdDtxR (mutant) + Cd<br />
-'''DtxR complex with metal and DNA'''
+*DtxR complex with metal and DNA
-[[1ddn]], [[1f5t]] – CdDtxR (mutant) + Ni + DNA<br />
+**[[1ddn]], [[1f5t]] – CdDtxR (mutant) + Ni + DNA<br />
-[[1c0w]] – CdDtxR + Co + DNA<br />
+**[[1c0w]] – CdDtxR + Co + DNA<br />
+}}
+== References ==
+<references/>
+[[Category:Topic Page]]