6glg: Difference between revisions

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-'''Unreleased structure'''
-The entry 6glg is ON HOLD
+==Crystal structure of hMTH1 F27A in complex with LW14 in the presence of acetate==
+<StructureSection load='6glg' size='340' side='right' caption='[[6glg]], [[Resolution|resolution]] 1.31&Aring;' scene=''>
-Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6glg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GLG FirstGlance]. <br>
-Description: hMTH1 F27A in complex with LW14
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BU8:1~{H}-imidazo[4,5-b]pyridin-2-amine'>BU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6glg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glg OCA], [http://pdbe.org/6glg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6glg RCSB], [http://www.ebi.ac.uk/pdbsum/6glg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6glg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Caflisch, A]]
+[[Category: Eberle, S A]]
+[[Category: Sledz, P]]
 [[Category: Wiedmer, L]]
-[[Category: Sledz, P]]
+[[Category: Complex]]
-[[Category: Eberle, S.A]]
+[[Category: Dna repair]]
+[[Category: Fragment]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor]]