Tuba: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) New page: <StructureSection load='4cc2' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for your page '''Tuba'''. Click above on '''edit this page''' t... |
Michal Harel (talk | contribs) No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='4cc2' size='340' side='right' caption='Human Tuba 6th SH3 domain (grey) complex with N-WASP peptide (green), glycerol and Cl- ion (PDB code [[4cc2]])' scene=''> | |||
== Function == | |||
'''Tuba''' or '''dynamin-binding protein''' is a scaffold protein found in brain synapses which brings together dynamin and actin regulatory proteins. The N-terminal SH3 domains bind dynamin and the C-terminal SH3 domain binds actin regulatory proteins<ref>PMID:14506234</ref>. | |||
For more details see [[Schubert lab: bacterial InIC disrupts human Tuba complexes]]. | |||
== Disease == | == Disease == | ||
Tuba deficiency causes and abnormal renal ciliary and morphogenetic phenotype. Tuba has a critical role in ciliogenesis and nephrogenesis by regulating Cdc42 activity<ref>PMID:26895965</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
Tuba contains 6 SH3 domains. The C-terminal 6th domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues<ref>PMID:24332715</ref>. | Tuba contains 6 SH3 domains. The C-terminal 6th SH3 domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues<ref>PMID:24332715</ref>. | ||
==Tuba 3D structures== | |||
See [[Tuba 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||