Colicin I receptor: Difference between revisions
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< | <StructureSection load='2hdi' size='350' side='right' caption='E. coli colicin I receptor (cyan) complexed with colicin Ia receptor-binding domain (green) and lauryl dimethylamine oxide (PDB entry [[2hdi]])' scene='46/466463/Cv/1'> | ||
'''Colicin I receptor''' (Cir) is | == Function == | ||
'''Colicin I receptor''' (Cir) is a TonB-dependent transporter of E. coli outer membrane transports Fe+3 bound to catecholates. Cir is used by [[Colicin|colicin]] Ia to penetrate the cell. Upon binding to colicin Ia Cir changes its conformation enabling the colicin to insert into the inner membrane forming a voltage-dependent ion channel resulting in killing the bacteria. | |||
== Structural highlights == | |||
Cir contains an N-terminal <scene name='46/466463/Cv/2'>plug domain</scene> inserted inside a <scene name='46/466463/Cv/5'>22-stranded transmembrane β barrel</scene>. The <scene name='46/466463/Cv/6'>colicin Ia R domain</scene> interacts with Cir plug domain.<ref>PMID:17464289</ref> | |||
__NOTOC__ | __NOTOC__ | ||
</StructureSection> | |||
== 3D Structures of Colicin I receptor == | == 3D Structures of Colicin I receptor == | ||
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[[2hdf]] – EcCir – ''Escherichia coli''<br /> | [[2hdf]] – EcCir – ''Escherichia coli''<br /> | ||
[[2hdi]] – EcCir + colicin Ia receptor-binding domain | [[2hdi]] – EcCir + colicin Ia receptor-binding domain | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||