Neuroligin-Neurexin Interaction: Difference between revisions
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<StructureSection load='' size='500' side='right' caption='Structure of Neurexin and Neuroligin, [[2wqz]]' scene='Neuroligin-Neurexin_Interaction/Opening/1'> | <StructureSection load='' size='500' side='right' caption='Structure of Neurexin LNS domain (yellow) and Neuroligin (green), [[2wqz]]' scene='Neuroligin-Neurexin_Interaction/Opening/1'> | ||
[[Image:NRXNNLGN2.png|250px|left]] '''Neurexins''' ('''NRXNs''') and '''Neuroligins''' ('''NLGNs''') are synaptic cell-adhesion molecules that form a connection between presynaptic and postsynaptic neurons at synapses. NLGNs, of which NLGN1-5 are the best characterized, are endogenous NRXN ligands.<ref name="Chih">PMID:15681343</ref> Upon binding NRXN, NLGNs mediate signaling across the synapse, recruit neutrotransmitter receptors, and shape neural networks and synaptic functions. Early experiments validated that NLGNs function at synapses by showing that NLGN expression in non-neuronal cells can cause presynaptic specializations to form on co-cultured neurons. The same is true for NRXNs which formed postsynaptic specializations.<ref name="Sudhof">PMID:18923512</ref> Subsequent analysis of gene-knockout mice surprisingly revealed that NLGNS and NRXNs are essential for synaptic function and organization, although do not appear to be critical for synapse formation.<ref name="Kat">PMID:17823315</ref> | [[Image:NRXNNLGN2.png|250px|left]] '''Neurexins''' ('''NRXNs''') and '''Neuroligins''' ('''NLGNs''') are synaptic cell-adhesion molecules that form a connection between presynaptic and postsynaptic neurons at synapses. NLGNs, of which NLGN1-5 are the best characterized, are endogenous NRXN ligands.<ref name="Chih">PMID:15681343</ref> Upon binding NRXN, NLGNs mediate signaling across the synapse, recruit neutrotransmitter receptors, and shape neural networks and synaptic functions. Early experiments validated that NLGNs function at synapses by showing that NLGN expression in non-neuronal cells can cause presynaptic specializations to form on co-cultured neurons. The same is true for NRXNs which formed postsynaptic specializations.<ref name="Sudhof">PMID:18923512</ref> Subsequent analysis of gene-knockout mice surprisingly revealed that NLGNS and NRXNs are essential for synaptic function and organization, although do not appear to be critical for synapse formation.<ref name="Kat">PMID:17823315</ref> | ||
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==Page Development== | |||
This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University. | |||
==Additional Structures of Neuroligin and Neurexin== | ==Additional Structures of Neuroligin and Neurexin== | ||