Z-DNA: Difference between revisions
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<StructureSection load='Z-DNA.pdb' size=' | <StructureSection load='Z-DNA.pdb' size='350' side='right' scene='Z-DNA/Z-dna_new/1' caption=''> | ||
'''Z-DNA''' <scene name='Z-DNA/Z-dna_new/1'>(default scene)</scene> is a form of DNA that has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/3'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in [http://proteopedia.org/wiki/index.php/Syn_and_anti_nucleosides anti-conformation and syn conformation]. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> This DNA form is thought to play a role in the regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | '''Z-DNA''' <scene name='Z-DNA/Z-dna_new/1'>(default scene)</scene> is a form of DNA that has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/3'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in [http://proteopedia.org/wiki/index.php/Syn_and_anti_nucleosides anti-conformation and syn conformation]. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> This DNA form is thought to play a role in the regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | ||
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</StructureSection> | </StructureSection> | ||
__NOTOC__ | __NOTOC__ | ||
== Movie Depicting ADAR1 binding to Z-DNA == | == Movie Depicting ADAR1 binding to Z-DNA == | ||
<html5media height=" | <html5media height="315" width="560">http://www.youtube.com/embed/tvrWkld8TBY</html5media> | ||
== Comparison of the three helices and helical parameters of DNA == | == Comparison of the three helices and helical parameters of DNA == | ||
''Sources''<ref>http://203.129.231.23/indira/nacc/</ref> | ''Sources''<ref>http://203.129.231.23/indira/nacc/</ref> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1woe]], [[3qba]], [[1i0t]], [[6aqt]], [[6aqv]], [[6aqw]], [[6aqx]], [[2ie1]], [[1da1]], [[1ick]], [[313d]], [[314d]], [[390d]], [[391d]], [[392d]], [[3p4j]], [[3qba]], [[3wbo]], [[400d]], [[4fs5]], [[4fs6]], [[4hif]], [[4hig]], [[2hto]], [[2htt]], [[4r15]], [[4xsn]], [[ | [[1woe]], [[3qba]], [[1i0t]], [[6aqt]], [[6aqv]], [[6aqw]], [[6aqx]], [[2ie1]], [[1da1]], [[1ick]], [[313d]], [[314d]], [[390d]], [[391d]], [[392d]], [[3p4j]], [[3qba]], [[3wbo]], [[400d]], [[4fs5]], [[4fs6]], [[4hif]], [[4hig]], [[2hto]], [[2htt]], [[4r15]], [[4xsn]], [[6bst]] – ZDNA hexamer CGCGCG<br /> | ||
[[1v9g]] – ZDNA hexamer CGCGCG - Neutron<br /> | [[1v9g]] – ZDNA hexamer CGCGCG - Neutron<br /> | ||
[[1tne]] – ZDNA hexamer CGCGCG - NMR<br /> | [[1tne]] – ZDNA hexamer CGCGCG - NMR<br /> | ||