6fig: Difference between revisions

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-'''Unreleased structure'''
-The entry 6fig is ON HOLD
+==Crystal structure of the ANX1 ectodomain from Arabidopsis thaliana==
+<StructureSection load='6fig' size='340' side='right' caption='[[6fig]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6fig]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FIG FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fig OCA], [http://pdbe.org/6fig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fig RCSB], [http://www.ebi.ac.uk/pdbsum/6fig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fig ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ANX1_ARATH ANX1_ARATH]] Receptor-like protein kinase that controls pollen tube behavior by directing rupture at proper timing to release the sperm cell.<ref>PMID:19646876</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Complex cell-to-cell communication between the male pollen tube and the female reproductive organs is required for plant fertilization. A family of Catharanthus roseus receptor kinase 1-like (CrRLK1L) membrane receptors has been genetically implicated in this process. Here, crystal structures of the CrRLK1Ls ANXUR1 and ANXUR2 are reported at 1.48 and 1.1 A resolution, respectively. The structures reveal a novel arrangement of two malectin-like domains connected by a short beta-hairpin linker and stabilized by calcium ions. The canonical carbohydrate-interaction surfaces of related animal and bacterial carbohydrate-binding modules are not conserved in plant CrRLK1Ls. In line with this, the binding of chemically diverse oligosaccharides to ANXUR1 and HERCULES1 could not be detected. Instead, CrRLK1Ls have evolved a protein-protein interface between their malectin domains which forms a deep cleft lined by highly conserved aromatic and polar residues. Analysis of the glycosylation patterns of different CrRLK1Ls and their oligomeric states suggests that this cleft could resemble a binding site for a ligand required for receptor activation of CrRLK1Ls.
-Authors:
+Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction.,Moussu S, Augustin S, Roman AO, Broyart C, Santiago J Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):671-680. doi:, 10.1107/S205979831800774X. Epub 2018 Jun 27. PMID:29968676<ref>PMID:29968676</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6fig" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Santiago, J]]
+[[Category: Arabidopsis thaliana]]
+[[Category: Malectin-like domain]]
+[[Category: Membrane protein]]
+[[Category: Plant protein]]
+[[Category: Receptor kinase]]