Cluster of Differentiation CD38: Difference between revisions

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Alexander Berchansky, Michal Harel, Jaime Prilusky

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-{{STRUCTURE_3gc6|  PDB=3gc6  | SIZE=400| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Glycosylated Cluster of Differentiation 38 (CD38) complex with sulfate [[3gc6]] }}
+<StructureSection load='2i65' size='450' side='right' scene='42/422415/Cv/3' caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'>
-[[Cluster of Differentiation 38]] (CD38), known also as ''ADP-ribosyl cyclase 1'' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR).  It is found on the surface of immune cells.  It also functions in cell adhesion, signal transduction and Ca++ signaling.
+__TOC__
-{{TOC limit|limit=2}}
+== Function ==
+[[Cluster of Differentiation 38]] (CD38), known also as '''ADP-ribosyl cyclase 1''' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR).  It is found on the surface of immune cells.  It also functions in cell adhesion, signal transduction and Ca+2 signaling.  '''ADP-ribosyl cyclase''' (ADPRC) is the ''Aplysia californica'' homolog of CD38.  It  catalyzes the synthesis and hydrolysis of cyclic ADP-ribose.  It uses   NAD+ as substrate and produces cyclic ADP-ribose (cADPR).<ref>PMID:16154090</ref>
+== Relevance ==
+CD38 is used as a marker for cell activation and for leukemia.
+== Structural highlights ==
+<scene name='42/422415/Cv/4'>CD38 active site contains NAD</scene>.<ref>PMID:16951430</ref>
+</StructureSection>
 == 3D Structures of Cluster of Differentiation 38 ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-=== CD38 ===
+* CD38
-[[3gc6]] – bCD38 - bovine<br />
+**[[3gc6]] – bCD38 - bovine<br />
-[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br />
+**[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br />
-[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br />
+**[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br />
-[[2ef1]] - hCD38 enzymatic domain – human<br />
+**[[2ef1]] - hCD38 enzymatic domain – human<br />
-[[1yh3]] - hCD38 enzymatic domain (mutant)<br />
+**[[1yh3]] - hCD38 enzymatic domain (mutant)<br />
-[[1zvm]] -  hCD38 (mutant)<br />
+**[[1zvm]] -  hCD38 (mutant)<br />
 **[[1isf]] – hADPRC2 (mutant) <br />
-=== CD38+ligand ===
+* CD38+ligand
+**[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br />
+**[[3f6y]] – hCD38 enzymatic domain+Ca++<br />
+**[[3dzf]] - hCD38 enzymatic domain+intermediate<br />
+**[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br />
+**[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br />
+**[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br />
+**[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br />
+**[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br />
+**[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br />
+**[[3u4h]], [[3u4i]] - hCD38 enzymatic domain (mutant)+cIDPR<br />
+**[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br />
+**[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br />
+**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
+**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
+**[[4cmh]] - hCD38 enzymatic domain + antibody<br />
+**[[2i65]] – hCD38+NAD<br />
+**[[3kou]] - hCD38+NAD derivative<br />
+**[[2i67]] - hCD38 (mutant)+ADPR<br />
+**[[2hct]] -  hCD38 enzymatic domain (mutant)+NMN<br />
+**[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br />
+**[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB<br />
+**[[3rok]], [[3rom]] - hCD38 (mutant) + arabinitol derivative<br />
+**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
+**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
+**[[3p5s]] - bADPRC + arabinitol derivative<br />
+*ADPRC
+**[[1r12]] - AcADPRC - ''Aplysia californica''<br />
+**[[1r0s]] – AcADPRC (mutant) <br />
+*ADPRC+ligand
+**[[1r15]] -  AcADPRC+nicotinamide<br />
+**[[3i9j]] – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI<br />
+**[[3i9k]] – AcADPRC (mutant)+NAD<br />
+**[[3i9l]] – AcADPRC (mutant)+N1-CIDPR<br />
+**[[3i9o]] – AcADPRC+Ribosyl-2F-ADPR<br />
+**[[3zwx]], [[3zwy]] – AcADPRC + 8-Br-ADPR<br />
+**[[1r16]] -  AcADPRC+3-pyridinylcarbinol<br />
+**[[3zwm]] – AcADPRC + NAD + cADPR<br />
+**[[3zwn]] – AcADPRC + NGD + cGDPR<br />
+**[[3zwo]] – AcADPRC + NGD + GDPR<br />
+**[[3zwp]], [[3zwv]], [[3zww]] – AcADPRC+ diphosphate ribosyl ara-2F-ADPR<br />
-[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br />
+}}
-[[3f6y]] – hCD38 enzymatic domain+Ca++<br />
+== References ==
-[[3dzf]] - hCD38 enzymatic domain+intermediate<br />
+<references/>
-[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br />
-[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br />
-[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br />
-[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br />
-[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br />
-[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br />
-[[3u4h]], [[3u4i]] - hCD38 enzymatic domain (mutant)+cIDPR<br />
-[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br />
-[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br />
-[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
-[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
-[[2i65]] – hCD38+NAD<br />
-[[2i66]] - hCD38 (mutant)+GDP intermediate<br />
-[[2i67]] - hCD38 (mutant)+ADPR<br />
-[[2hct]] -  hCD38 enzymatic domain (mutant)+NMN<br />
-[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br />
-[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB<br />
-[[3rok]], [[3rom]] - hCD38 (mutant) + arabinitol derivative<br />
-[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
-[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
-[[1isf]] – hCD38 (mutant)<br />
 [[Category:Topic Page]]