Factor XIII: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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-[[Image:1ggt.png|left|200px|thumb|Crystal Structure of human Factor XIII, [[1ggt]]]]
+<StructureSection load='1ggt' size='350' side='right' caption='Human Factor XIII dimer (PDB entry [[1ggt]])' scene='Factor_XIII/Cv/1'>
-{{STRUCTURE_1ggt|  PDB=1ggt  | SIZE=300| SCENE=Factor_XIII/Cv/1 |right|CAPTION=Human Factor XIII dimer, [[1ggt]] }}
+== Function ==
-[[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot.  FXIII is activated by thrombin which cleaves it and releases an activation peptide.  The images at the left and at the right correspond to one representative FXIII, ''i.e.'' the crystal structure of human Factor XIII ([[1ggt]]).
+[[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot.  FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>.
-{{TOC limit|limit=2}}
+== Disease ==
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+FXIII deficiency causes internal bleeding.
+</StructureSection>
 == 3D Structures of Factor XIII ==
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 [[1f13]] - hFXIII zymogen subunit A dimer<br />
 [[4kty]] - hFXIII subunit A + peptide-like ligand<br />
+[[5mhl]], [[5mhm]], [[5mhn]], [[5mho]] - hFXIII subunit A (mutant) + peptide inhibitor<br />
 [[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br />
-[[1de7]] – fFXIII activation peptide + α-thrombin<br />
+[[1de7]] – hFXIII activation peptide + α-thrombin<br />
+== References ==
+<references/>
 [[Category:Topic Page]]