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| | | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1y8e was removed. |
| ==VCP:Suramin Complex==
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| <StructureSection load='1y8e' size='340' side='right' caption='[[1y8e]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| == Structural highlights ==
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| <table><tr><td colspan='2'>[[1y8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y8E FirstGlance]. <br>
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| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SVR:8,8-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC+ACID'>SVR</scene></td></tr>
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| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g44|1g44]], [[1rid|1rid]]</td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8e OCA], [http://pdbe.org/1y8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y8e RCSB], [http://www.ebi.ac.uk/pdbsum/1y8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8e ProSAT]</span></td></tr>
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| </table>
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| == Function ==
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| [[http://www.uniprot.org/uniprot/VCP_VACCW VCP_VACCW]] Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b.<ref>PMID:1731333</ref> <ref>PMID:18287241</ref>
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| == Evolutionary Conservation ==
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| [[Image:Consurf_key_small.gif|200px|right]]
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| Check<jmol>
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| <jmolCheckbox>
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| <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y8/1y8e_consurf.spt"</scriptWhenChecked>
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| <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| <text>to colour the structure by Evolutionary Conservation</text>
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| </jmolCheckbox>
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| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8e ConSurf].
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| <div style="clear:both"></div>
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Suramin is a competitive inhibitor of heparin binding to many proteins, including viral envelope proteins, protein tyrosine phosphatases, and fibroblast growth factors (FGFs). It has been clinically evaluated as a potential therapeutic in treatment of cancers caused by unregulated angiogenesis, triggered by FGFs. Although it has shown clinical promise in treatment of several cancers, suramin has many undesirable side effects. There is currently no experimental structure that reveals the molecular interactions responsible for suramin inhibition of heparin binding, which could be of potential use in structure-assisted design of improved analogues of suramin. We report the structure of suramin, in complex with the heparin-binding site of vaccinia virus complement control protein (VCP), which interacts with heparin in a geometrically similar manner to many FGFs. The larger than anticipated flexibility of suramin manifested in this structure, and other details of VCP-suramin interactions, might provide useful structural information for interpreting interactions of suramin with many proteins.
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| Structural basis for antagonism by suramin of heparin binding to vaccinia complement protein.,Ganesh VK, Muthuvel SK, Smith SA, Kotwal GJ, Murthy KH Biochemistry. 2005 Aug 16;44(32):10757-65. PMID:16086578<ref>PMID:16086578</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 1y8e" style="background-color:#fffaf0;"></div>
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| ==See Also==
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| *[[Retractions and Fraud|Retractions and Fraud]]
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Vaccinia virus]]
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| [[Category: Ganesh, V K]]
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| [[Category: Kotwal, G J]]
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| [[Category: Murthy, K H]]
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| [[Category: Muthuvel, S K]]
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| [[Category: Smith, S A]]
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| [[Category: Beta barrel]]
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| [[Category: Viral protein]]
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For additional information see 2009, December: at Retractions and Fraud.
REMOVED: The PDB entry 1y8e was removed.