Eric Comeau/ sandbox: Difference between revisions
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== Sickle Cell Hemoglobin == | == Sickle Cell Hemoglobin == | ||
<StructureSection load=' | <StructureSection load='2hbs' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page '''Eric Comeau/ sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Eric Comeau/ sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== | == Physical model == | ||
The 3D-printed models are of the tetramer, with one beta subunit valine marked with a blue rod. One hydrophobic surface patch is marked with a hole. In the browser, the <scene name='61/611454/One_with_val/1'>tetramer</scene> is shown in red (alpha subunits) and orangered (beta subunits), with both valines shown in blue. In a second scene, <scene name='61/611454/Two_with_val/1'>two interacting tetramers</scene> are shown. You can see that one of the four valines is buried in the contact area between the two tetramers. The <scene name='61/611454/Val_and_patch/2'>hydrophobic patch</scene> (shown in gray) consists of Phe 85 and Leu 88 side chains in an indentation of the protein's surface. | |||
== Sickle Cell Anemia == | == Sickle Cell Anemia == | ||
<scene name='61/611454/Hemoglobin/2'>Full Protein | |||
<scene name='61/611454/Hemoglobin/7'>Two hemoglobin proteins with mutated Beta protein</scene> | |||
The <scene name='61/611454/Hemoglobin/9'>hydrophobic patch</scene> is shown in gray, the mutations to valine in blue. | |||
<scene name='61/611454/Hemoglobin/8'>Hemoglobin and Valine</scene> | |||
<scene | |||
name='61/611454/Hemoglobin/2'>Full Protein</scene> | |||
== Relevance == | == Relevance == | ||
Latest revision as of 23:05, 11 January 2018
Sickle Cell HemoglobinSickle Cell Hemoglobin
This is a default text for your page Eric Comeau/ sandbox. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Physical modelThe 3D-printed models are of the tetramer, with one beta subunit valine marked with a blue rod. One hydrophobic surface patch is marked with a hole. In the browser, the is shown in red (alpha subunits) and orangered (beta subunits), with both valines shown in blue. In a second scene, are shown. You can see that one of the four valines is buried in the contact area between the two tetramers. The (shown in gray) consists of Phe 85 and Leu 88 side chains in an indentation of the protein's surface. Sickle Cell Anemia
The is shown in gray, the mutations to valine in blue.
RelevanceStructural highlightsThis is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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ReferencesReferences
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644