Eric Comeau/ sandbox: Difference between revisions
Eric Comeau (talk | contribs) New page: == Sickle Cell Hemoglobin == <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for your page '''Eric Comeau/ sandb... |
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== Sickle Cell Hemoglobin == | == Sickle Cell Hemoglobin == | ||
<StructureSection load=' | <StructureSection load='2hbs' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page '''Eric Comeau/ sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Eric Comeau/ sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== | == Physical model == | ||
The 3D-printed models are of the tetramer, with one beta subunit valine marked with a blue rod. One hydrophobic surface patch is marked with a hole. In the browser, the <scene name='61/611454/One_with_val/1'>tetramer</scene> is shown in red (alpha subunits) and orangered (beta subunits), with both valines shown in blue. In a second scene, <scene name='61/611454/Two_with_val/1'>two interacting tetramers</scene> are shown. You can see that one of the four valines is buried in the contact area between the two tetramers. The <scene name='61/611454/Val_and_patch/2'>hydrophobic patch</scene> (shown in gray) consists of Phe 85 and Leu 88 side chains in an indentation of the protein's surface. | |||
== Sickle Cell Anemia == | == Sickle Cell Anemia == | ||
<scene name='61/611454/Hemoglobin/7'>Two hemoglobin proteins with mutated Beta protein</scene> | |||
The <scene name='61/611454/Hemoglobin/9'>hydrophobic patch</scene> is shown in gray, the mutations to valine in blue. | |||
<scene name='61/611454/Hemoglobin/8'>Hemoglobin and Valine</scene> | |||
<scene | |||
name='61/611454/Hemoglobin/2'>Full Protein</scene> | |||
== Relevance == | == Relevance == | ||