3kbb: Difference between revisions
New page: '''Unreleased structure''' The entry 3kbb is ON HOLD Authors: Strange, R.W., Antonyuk, S.V., Ellis, M.J., Bessho, Y., Kuramitsu, S., Yokoyama, S., Hasnain, S.S., RIKEN Structural Genomi... |
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==Crystal structure of putative beta-phosphoglucomutase from Thermotoga maritima== | |||
<StructureSection load='3kbb' size='340' side='right' caption='[[3kbb]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3kbb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pib 2pib]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KBB FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bpgm, tm_1254 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbb OCA], [http://pdbe.org/3kbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kbb RCSB], [http://www.ebi.ac.uk/pdbsum/3kbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/P1254_THEMA P1254_THEMA]] Displays high phosphatase activity toward erythrose 4-phosphate, fructose 6-phosphate, 2-deoxyglucose 6-phosphate, and mannose 6-phosphate. May have a role in the intracellular metabolism of many phosphorylated carbohydrates. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kbb_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kbb ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of TM1254, a putative beta-phosphoglucomutase from T. maritima, was determined to 1.74 A resolution in a high-throughput structural genomics programme. Diffraction data were obtained from crystals belonging to space group P22(1)2(1), with unit-cell parameters a = 48.16, b = 66.70, c = 83.80 A, and were refined to an R factor of 19.2%. The asymmetric unit contained one protein molecule which is comprised of two domains. Structural homologues were found from protein databases that confirmed a strong resemblance between TM1254 and members of the haloacid dehalogenase (HAD) hydrolase family. | |||
Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima.,Strange RW, Antonyuk SV, Ellis MJ, Bessho Y, Kuramitsu S, Shinkai A, Yokoyama S, Hasnain SS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1218-21. Epub 2009 Nov 27. PMID:20054115<ref>PMID:20054115</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3kbb" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Thema]] | |||
[[Category: Antonyuk, S V]] | |||
[[Category: Bessho, Y]] | |||
[[Category: Ellis, M J]] | |||
[[Category: Hasnain, S S]] | |||
[[Category: Kuramitsu, S]] | |||
[[Category: Structural genomic]] | |||
[[Category: Strange, R W]] | |||
[[Category: Yokoyama, S]] | |||
[[Category: Arbohydrate metabolism]] | |||
[[Category: Cobalt]] | |||
[[Category: Hydrolase]] | |||
[[Category: Magnesium]] | |||
[[Category: Manganese]] | |||
[[Category: Metal-binding]] | |||
[[Category: National project on protein structural and functional analyse]] | |||
[[Category: Nickel]] | |||
[[Category: Nppsfa]] | |||
[[Category: Rsgi]] | |||
[[Category: Thermotoga maritima]] | |||