Fasciculin: Difference between revisions

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[[Image:1fas.png|left|200px|thumb|Crystal Structure of Fasciculin [[1fas]]]]
<StructureSection load='' size='350' side='right' caption='Structure of Fasciculin 1 (PDB entry [[1fas]])' scene='Fasciculin/Cv/1'>
{{STRUCTURE_1fas|  PDB=1fas  | SIZE=300| SCENE=Fasciculin/Cv/1 |right|CAPTION=Fasciculin 1 [[1fas]] }}


[[Fasciculin|Fasciculins]] (FAS) are toxins produced by the snake green mamba.  FAS1 and FAS2 are known to bind to [[acetylcholinesterase|acetylcholinesterase]] (AChE)  and cause severe fasciculations. The images at the left and at the right correspond to one representative FAS, ''i.e.'' the crystal structure of Fasciculin 1 ([[1fas]]).  For toxins in Proteopedia see [[Toxins]].
[[Fasciculin|Fasciculins]] (FAS) are toxins produced by the snake green mamba.  FAS1 and FAS2 are known to bind to [[acetylcholinesterase|acetylcholinesterase]] (AChE)  and cause severe fasciculations<ref>PMID:6530667</ref> .  For toxins in Proteopedia see [[Toxins]].




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</StructureSection>
== 3D Structures of Fasciculin ==
== 3D Structures of Fasciculin ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


=== Fasciculin ===
* Fasciculin  


[[1fas]] – FAS1 <br />
**[[1fas]] – FAS1 <br />
[[1fsc]] - FAS2<br />
**[[1fsc]] - FAS2<br />


=== FAS+ AChE ===
* FAS+ AChE  


[[2x8b]], [[1b41]], [[4ey8]], [[4bdt]] – FAS2+hAChE – human<br />
**[[2x8b]], [[1b41]], [[4ey8]], [[4bdt]] – FAS2+hAChE – human<br />
[[1f8u]] - FAS2+hAChE (mutant)<br />
**[[1f8u]] - FAS2+hAChE (mutant)<br />
[[1ku6]], [[1mah]] - FAS2+mAChE – mouse<br />
**[[1ku6]], [[1mah]] - FAS2+mAChE – mouse<br />
[[1fss]] - FAS2+AChE – ''Torpedo californica''<br />
**[[1fss]] - FAS2+AChE – ''Torpedo californica''<br />
}}
== References ==
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 13:44, 20 October 2017


Fasciculins (FAS) are toxins produced by the snake green mamba. FAS1 and FAS2 are known to bind to acetylcholinesterase (AChE) and cause severe fasciculations[1] . For toxins in Proteopedia see Toxins.


Structure of Fasciculin 1 (PDB entry 1fas)

Drag the structure with the mouse to rotate

3D Structures of Fasciculin3D Structures of Fasciculin

Updated on 20-October-2017

ReferencesReferences

  1. ↑ Karlsson E, Mbugua PM, Rodriguez-Ithurralde D. Fasciculins, anticholinesterase toxins from the venom of the green mamba Dendroaspis angusticeps. J Physiol (Paris). 1984;79(4):232-40. PMID:6530667

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman
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