Eglin: Difference between revisions

Latest revision as of 20:57, 19 October 2017

Eglin C is a serine proteinase inhibitor isolated from leech. ^[1]

Relevance

Eglin C and its mutants are tested as protease inhibitor drugs.

Cleaved leech Eglin. Residues 1-45 (grey) and 46-70 (green) (PDB code 1egp).

Drag the structure with the mouse to rotate

3D Structures of Eglin3D Structures of Eglin

Updated on 19-October-2017

1egp – lEglin-C – leech
1egl - lEglin-C – NMR
1sbn, 1sib, 1cse - lEglin-C+BsSubtilisin – Bacillus subtilis
2sec - lEglin-C+BlSubtilisin – Bacillus licheniformis
1acb - lEglin-C+bChymotrypsinogen – bovine
4b1t, 4b2a, 4b2b, 4b2c - lEglin-C (mutant) +bTrypsin (mutant)
1mee - lEglin-C+BpMesentericopeptidase – Bacillus pumilus
2tec, 3tec, 1tec - lEglin-C+TvThermitase – Thermoactinomyces vulgaris
4h4f - lEglin-C+ hChymotrypsin – human

ReferencesReferences

↑ McPhalen CA, James MN. Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo. Biochemistry. 1988 Aug 23;27(17):6582-98. PMID:3064813

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

[1] McPhalen CA, James MN. Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo. Biochemistry. 1988 Aug 23;27(17):6582-98. PMID:3064813

[1]

@@ Line 1: / Line 1: @@
-{{STRUCTURE_1egp|  PDB=1egp  | SIZE=300| SCENE=Eglin/Cv/1 |right|CAPTION=Cleaved leech Eglin.  Residues 1-45 (grey) and 46-70 (green) [[1egp]] }}
-[[Eglin]] C is a serine proteinase inhibitor isolated from leech. <ref>PMID:3064813</ref>
+<StructureSection load='1egp' size='350' side='right' caption='Cleaved leech Eglin.  Residues 1-45 (grey) and 46-70 (green) (PDB code [[1egp]]).' scene='Eglin/Cv/1'>
-{{TOC limit|limit=2}}
+'''Eglin C''' is a serine proteinase inhibitor isolated from leech. <ref>PMID:3064813</ref>
+== Relevance ==
+Eglin C and its mutants are tested as protease inhibitor drugs.
+</StructureSection>
 == 3D Structures of Eglin ==