Telethonin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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-[[Image:1ya5.png|left|200px|thumb|Crystal structure of telethonin in complex with titin domains z1z2, [[1ya5]]]]
+<StructureSection load='' size='350' side='right' scene='Telethonin/Cv/1' caption='Crystal structure of telethonin (dark green) in complex with titin domains z1z2 dimer (grey and light green) and sulfate (PDB code [[1ya5]])'>
-{{STRUCTURE_1ya5|  PDB=1ya5  | SIZE=400| SCENE=Telethonin/Cv/1 |right|CAPTION=Crystal structure of telethonin in complex with titin domains z1z2, [[1ya5]] }}
+== Function ==
+[[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains.  It is essential to sarcomer assembly<ref>PMID:11699871</ref>.  It is called [[titin]] cap protein.   See also [[Group:MUZIC:Telethonin]].
-[[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains.  It is essential to sarcomer assembly.  It is called [[titin]] cap protein. The images at the left and at the right correspond to one representative telethonin, ''i.e.'' the crystal structure of <scene name='Telethonin/Cv/2'>telethonin</scene> in complex with titin domains z1z2 ([[1ya5]]).  See also [[Group:MUZIC:Telethonin]].
-{{TOC limit|limit=2}}
+== Disease ==
+Mutations in telethonin lead to heart maladptation to biomechanical stress<ref>PMID:21799151</ref>.
+</StructureSection>
 == 3D Structures of Telethonin ==
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 [[2f8v]], [[1ya5]] - telethonin+ hTTN residues 1-196 - human
+== References ==
+<references/>
 [[Category:Topic Page]]