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Aricept Complexed with Acetylcholinesterase (Turkish): Difference between revisions

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<StructureSection load='1eve' size='450' side='right' scene='29/2908/1eve_e20_cartoon/1' caption=''>
[[Image:E2020_interactins_in_AChE_gorge.jpg|left|250px]]<br />
[[Image:E2020_interactins_in_AChE_gorge.jpg|left|250px]]<br />
{{STRUCTURE_1eve|  PDB=1eve  |  SCENE=Main_Page/E2020_in_ache_spinning/1  }}
'''Asetilkolinesteraz ile kompleks oluşturan, anti-Alzheimer ilacı, Aricept’in 3 boyutlu yapısı '''
'''Asetilkolinesteraz ile kompleks oluşturan, anti-Alzheimer ilacı, Aricept’in 3 boyutlu yapısı '''
(Ayrıca bakınız: [[AChE bivalent inhibitors (Part II)]] )
(Ayrıca bakınız: [[AChE bivalent inhibitors (Part II)]] )
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{{Clear}}
{{Clear}}
<applet load='1eve.pdb' size='500' frame='true' align='right' scene='Main_Page/E2020_in_ache_spinning/1' />
==Bulgular==
==Bulgular==
E2020-''Tc''AChE kompleksinin X-ray yapısı, E2020’nin aktif bölge oluğu boyunca, aktif bölgenin aniyonik alt biriminden (<scene name='1eve/E2020_close_up_with_84lbld/7'>W84</scene>), alttaki periferal aniyonik bölgeye (<scene name='1eve/E2020_close_up_with_84_279lbld/5'>W279</scene>'un yanı) uzanan, tepede ,korunmuş aromatik asit rezidüleri ile aromatik kümelenme etkileşimleri üzerinden <scene name='1eve/E2020_close_up_with_84_279/13'>benzersiz bir uyuma</scene> sahip olduğunu gösterir. E2020, direkt olarak katalitik triad veya 'oksianyon boşluğu' ile etkileşime girmezken, ancak <scene name='1eve/E20_interactionshown/8'>indirekt olarak </scene>solvent moleküller üzerinden interaksiyona girer.
E2020-''Tc''AChE kompleksinin X-ray yapısı, E2020’nin aktif bölge oluğu boyunca, aktif bölgenin aniyonik alt biriminden (<scene name='1eve/E2020_close_up_with_84lbld/7'>W84</scene>), alttaki periferal aniyonik bölgeye (<scene name='1eve/E2020_close_up_with_84_279lbld/5'>W279</scene>'un yanı) uzanan, tepede ,korunmuş aromatik asit rezidüleri ile aromatik kümelenme etkileşimleri üzerinden <scene name='1eve/E2020_close_up_with_84_279/13'>benzersiz bir uyuma</scene> sahip olduğunu gösterir. E2020, direkt olarak katalitik triad veya 'oksianyon boşluğu' ile etkileşime girmezken, ancak <scene name='1eve/E20_interactionshown/8'>indirekt olarak </scene>solvent moleküller üzerinden interaksiyona girer.
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==Bu Yapı Hakkında==
==Bu Yapı Hakkında==
1EVE, NAG ve E20 [http://en.wikipedia.org/wiki/ligands ligandlarına] sahip dizisi [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]’ya ait bir [http://en.wikipedia.org/wiki/Protein protein] yapısıdır. Aktif olarak [[Acetylcholinesterase|Asetilkolinesteraz]], EC numarası [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]dir. Tam kristalografik bilgi [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EVE OCA]‘dan edinilebilir.
1EVE, NAG ve E20 [http://en.wikipedia.org/wiki/ligands ligandlarına] sahip dizisi [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]’ya ait bir [http://en.wikipedia.org/wiki/Protein protein] yapısıdır. Aktif olarak [[Acetylcholinesterase|Asetilkolinesteraz]], EC numarası [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]dir. Tam kristalografik bilgi [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EVE OCA]‘dan edinilebilir.
 
</StructureSection>
==Kaynak==
==Kaynak==
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10368299 10368299]
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10368299 10368299]


See [[1eve (Chinese)]], [[1eve (French)]], [[1eve (Italian)]], [[1eve (Arabic)]], [[1eve (Russian)]], [[1eve (Spanish)]], & [[1eve]] - in English.
[[ar:Aricept_Complexed_with_Acetylcholinesterase (Arabic)]]
[[ca:Aricept_Complexed_with_Acetylcholinesterase (Catalan)]]
[[zh:Aricept_Complexed_with_Acetylcholinesterase (Chinese)]]
[[cs:Aricept_Complexed_with_Acetylcholinesterase (Czech)]]
[[de:Aricept_Complexed_with_Acetylcholinesterase (German)]]
[[en:Aricept_Complexed_with_Acetylcholinesterase]]
[[es:Aricept_Complexed_with_Acetylcholinesterase (Spanish)]]
[[fr:Aricept_Complexed_with_Acetylcholinesterase (French)]]
[[he:Aricept_Complexed_with_Acetylcholinesterase (Hebrew)]]
[[it:Aricept_Complexed_with_Acetylcholinesterase (Italian)]]
[[ru:Aricept_Complexed_with_Acetylcholinesterase (Russian)]]
[[sk:Aricept_Complexed_with_Acetylcholinesterase (Slovak)]]
[[vi:Aricept_Complexed_with_Acetylcholinesterase (Vietnamese)]]
[[tr:Aricept_Complexed_with_Acetylcholinesterase (Turkish)]]


[[ar:1eve (Arabic)]]
[[en:1eve]]
[[es:1eve (Spanish)]]
[[fr:1eve (French)]]
[[ru:1eve (Russian)]]
[[zh:1eve (Chinese)]]


[[Category: Acetylcholinesterase]]
[[Category: Acetylcholinesterase]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Samet Serdar Yildirim, Joel L. Sussman, Jaime Prilusky, Sezen Balli, Eran Hodis, Alexander Berchansky, Fred Vellieux
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