2eaw: Difference between revisions

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[[Image:2eaw.gif|left|200px]]
==Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)==
<StructureSection load='2eaw' size='340' side='right' caption='[[2eaw]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2eaw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eaw OCA], [http://pdbe.org/2eaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eaw RCSB], [http://www.ebi.ac.uk/pdbsum/2eaw PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eaw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eaw ConSurf].
<div style="clear:both"></div>


{{Structure
==See Also==
|PDB= 2eaw |SIZE=350|CAPTION= <scene name='initialview01'>2eaw</scene>, resolution 2.88&Aring;
*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
|SITE=
== References ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
<references/>
|ACTIVITY=
__TOC__
|GENE= UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
</StructureSection>
}}
[[Category: Human]]
 
[[Category: Liu, Y]]
'''Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)'''
[[Category: Pai, E F]]
 
[[Category: Tang, H L]]
 
[[Category: C-terminal domain]]
==Disease==
[[Category: Lyase]]
Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
 
[[Category: Ump synthase]]
==About this Structure==
2EAW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAW OCA].
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Liu, Y.]]
[[Category: Pai, E F.]]
[[Category: Tang, H L.]]
[[Category: SO4]]
[[Category: c-terminal domain]]
[[Category: human]]
[[Category: orotidine 5'-monophosphate decarboxylase]]
[[Category: ump synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:37:41 2008''

Latest revision as of 09:13, 8 February 2016

Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)

Structural highlights

2eaw is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:UMPS (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Disease

[UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Suchi M, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson ME, Ogawa H, Wada Y. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. Am J Hum Genet. 1997 Mar;60(3):525-39. PMID:9042911

2eaw, resolution 2.88Å

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