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[[Image:2cff.jpg|left|200px]]<br /><applet load="2cff" size="350" color="white" frame="true" align="right" spinBox="true"
==CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)==
caption="2cff, resolution 2.500&Aring;" />
<StructureSection load='2cff' size='340' side='right' caption='[[2cff]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
'''CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)'''<br />
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2cff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFF FirstGlance]. <br>
==About this Structure==
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
2CFF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/1-(5-phosphoribosyl)-5-_((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide_isomerase 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.16 5.3.1.16] Known structural/functional Site: <scene name='pdbsite=AC1:Mpd+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFF OCA].  
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qo2|1qo2]]</td></tr>
[[Category: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-(5-phosphoribosyl)-5-_((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide_isomerase 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.16 5.3.1.16] </span></td></tr>
[[Category: Single protein]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cff OCA], [http://pdbe.org/2cff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cff RCSB], [http://www.ebi.ac.uk/pdbsum/2cff PDBsum]</span></td></tr>
[[Category: Thermotoga maritima]]
</table>
[[Category: He, C.]]
== Evolutionary Conservation ==
[[Category: Kuper, J.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Sterner, R.]]
Check<jmol>
[[Category: Wilmmans, M.]]
  <jmolCheckbox>
[[Category: MPD]]
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cff_consurf.spt"</scriptWhenChecked>
[[Category: amino-acid biosynthesis]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: histidine biosynthesis]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: isomerase]]
  </jmolCheckbox>
[[Category: thermophilic protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cff ConSurf].
 
<div style="clear:both"></div>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:34:42 2008''
__TOC__
</StructureSection>
[[Category: Atcc 43589]]
[[Category: He, C]]
[[Category: Kuper, J]]
[[Category: Sterner, R]]
[[Category: Wilmmans, M]]
[[Category: Amino-acid biosynthesis]]
[[Category: Histidine biosynthesis]]
[[Category: Isomerase]]
[[Category: Thermophilic protein]]

Latest revision as of 08:36, 7 February 2016

CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)

Structural highlights

2cff is a 2 chain structure with sequence from Atcc 43589. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase, with EC number 5.3.1.16
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2cff, resolution 2.50Å

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