SCF-KIT: Difference between revisions
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<StructureSection load='2E9W' size='340' side='right' caption='Kit tyrosine kinase (pink, yellow) complex with stem cell growth factor receptor (grey, green) (PDB code [[2e9w]])' scene='> | <StructureSection load='2E9W' size='340' side='right' caption='Glycosylated Kit tyrosine kinase (pink, yellow) complex with stem cell growth factor receptor (grey, green) (PDB code [[2e9w]])' scene='> | ||
== Introduction == | == Introduction == | ||
'''Stem cell factor (SCF)''' is a cytokine that mediates its diverse cellular responses by binding to and activating the [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase (RTK)]. [https://en.wikipedia.org/wiki/CD117 KIT] (also known as [https://en.wikipedia.org/wiki/Stem_cell_factor SCF]receptor), functions as a noncovalent homodimer, and both membrane-anchored and soluble forms of SCF have been described. | '''Stem cell factor (SCF)''' is a cytokine that mediates its diverse cellular responses by binding to and activating the [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase (RTK)]. [https://en.wikipedia.org/wiki/CD117 KIT] (also known as [https://en.wikipedia.org/wiki/Stem_cell_factor SCF]receptor), functions as a noncovalent homodimer, and both membrane-anchored and soluble forms of SCF have been described. | ||