1vrd: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1vrd.gif|left|200px]]
+==Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution==
+<StructureSection load='1vrd' size='340' side='right' caption='[[1vrd]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1vrd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VRD FirstGlance]. <br>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TM1347 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vrd OCA], [http://pdbe.org/1vrd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vrd RCSB], [http://www.ebi.ac.uk/pdbsum/1vrd PDBsum], [http://www.topsan.org/Proteins/JCSG/1vrd TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q9X168_THEMA Q9X168_THEMA]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/1vrd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
- {{Structure
+==See Also==
-|PDB= 1vrd |SIZE=350|CAPTION= <scene name='initialview01'>1vrd</scene>, resolution 2.18&Aring;
+*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
-|SITE=
+__TOC__
-|LIGAND=
+</StructureSection>
-|ACTIVITY= [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205]
-|GENE= TM1347 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 Thermotoga maritima MSB8])
-}}
-'''Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution'''
-==About this Structure==
-VRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRD OCA].
 [[Category: IMP dehydrogenase]]
-[[Category: Single protein]]
+[[Category: Thema]]
-[[Category: Thermotoga maritima msb8]]
+[[Category: Structural genomic]]
-[[Category: JCSG, Joint Center for Structural Genomics.]]
+[[Category: Inosine-5'-monophosphate dehydrogenase]]
-[[Category: inosine-5'-monophosphate dehydrogenase]]
+[[Category: Jcsg]]
-[[Category: jcsg]]
+[[Category: Oxidoreductase]]
-[[Category: joint center for structural genomic]]
+[[Category: PSI, Protein structure initiative]]
-[[Category: protein structure initiative]]
+[[Category: Tm1347]]
-[[Category: psi]]
-[[Category: structural genomic]]
-[[Category: tm1347]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:48:43 2008''